Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control

M. Berkelaar, E.M.W. Eekhoff, A.M.C. Bik-Simonis, D.I. Boomsma, M. Diamant, R.G. IJzerman, J.M. Dekker, L.M. 't Hart, E.J.C. de Geus

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Aims/hypothesis: We examined the effects of serum insulin levels on vagal control over the heart and tested the hypothesis that higher fasting insulin levels are associated with lower vagal control. We also examined whether experimentally induced increases in insulin by beta cell secretagogues, including glucagon-like peptide-1 (GLP-1), will decrease vagal control. Methods: Respiration and ECGs were recorded for 130 healthy participants undergoing clamps. Three variables of cardiac vagal effects (the root mean square of successive differences [rMSSD] in the interbeat interval of the heart rate [IBI], heart-rate variability [HRV] caused by peak-valley respiratory sinus arrhythmia [pvRSA], and high-frequency power [HF]) and heart rate (HR) were obtained at seven time points during the clamps, characterised by increasing levels of insulin (achieved by administering insulin plus glucose, glucose only, glucose and GLP-1, and glucose and GLP-1 combined with arginine). Results: Serum insulin level was positively associated with HR at all time points during the clamps except the first-phase hyperglycaemic clamp. Insulin levels were negatively correlated with variables of vagal control, reaching significance for rMSSD and log
Original languageEnglish
Pages (from-to)1436-1443
JournalDiabetologia
Volume56
Issue number6
Early online date13 Feb 2013
DOIs
Publication statusPublished - 2013

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