Effects of Salts on Internal DNA Pressure and Mechanical Properties of Phage Capsids

A. Evilevitch, W.H. Roos, I.L. Ivanovska, M Jeembaeva, B. Jonsson, G.J.L. Wuite

Research output: Contribution to JournalArticleAcademicpeer-review


Based on atomic force microscopy nanoindentation measurements of phage λ, we previously proposed a minimal model describing the effect of water hydrating DNA that strengthens viral capsids against external deformation at wild-type DNA packing density. Here, we report proof of this model by testing the prediction that DNA hydration forces can be dramatically decreased by addition of multivalent ions (Mg
Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalJournal of Molecular Biology
Issue number1
Publication statusPublished - 2011


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