Effects of sleep deprivation on neural functioning: an integrative review

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Sleep deprivation has a broad variety of effects on human performance and neural functioning that manifest themselves at different levels of description. On a macroscopic level, sleep deprivation mainly affects executive functions, especially in novel tasks. Macroscopic and mesoscopic effects of sleep deprivation on brain activity include reduced cortical responsiveness to incoming stimuli, reflecting reduced attention. On a microscopic level, sleep deprivation is associated with increased levels of adenosine, a neuromodulator that has a general inhibitory effect on neural activity. The inhibition of cholinergic nuclei appears particularly relevant, as the associated decrease in cortical acetylcholine seems to cause effects of sleep deprivation on macroscopic brain activity. In general, however, the relationships between the neural effects of sleep deprivation across observation scales are poorly understood and uncovering these relationships should be a primary target in future research. © 2007 Birkhäuser Verlag.
    Original languageEnglish
    Pages (from-to)934-946
    JournalCellular and Molecular Life Sciences
    Volume64
    DOIs
    Publication statusPublished - 2007

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    Sleep Deprivation
    Executive Function
    Brain
    Adenosine
    Cholinergic Agents
    Acetylcholine
    Neurotransmitter Agents
    Observation

    Cite this

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    title = "Effects of sleep deprivation on neural functioning: an integrative review",
    abstract = "Sleep deprivation has a broad variety of effects on human performance and neural functioning that manifest themselves at different levels of description. On a macroscopic level, sleep deprivation mainly affects executive functions, especially in novel tasks. Macroscopic and mesoscopic effects of sleep deprivation on brain activity include reduced cortical responsiveness to incoming stimuli, reflecting reduced attention. On a microscopic level, sleep deprivation is associated with increased levels of adenosine, a neuromodulator that has a general inhibitory effect on neural activity. The inhibition of cholinergic nuclei appears particularly relevant, as the associated decrease in cortical acetylcholine seems to cause effects of sleep deprivation on macroscopic brain activity. In general, however, the relationships between the neural effects of sleep deprivation across observation scales are poorly understood and uncovering these relationships should be a primary target in future research. {\circledC} 2007 Birkh{\"a}user Verlag.",
    author = "T.W. Boonstra and J.F. Stins and A. Daffertshofer and P.J. Beek",
    year = "2007",
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    Effects of sleep deprivation on neural functioning: an integrative review. / Boonstra, T.W.; Stins, J.F.; Daffertshofer, A.; Beek, P.J.

    In: Cellular and Molecular Life Sciences, Vol. 64, 2007, p. 934-946.

    Research output: Contribution to JournalArticleAcademicpeer-review

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    AU - Boonstra, T.W.

    AU - Stins, J.F.

    AU - Daffertshofer, A.

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