Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices

On behalf of the CranioSafe Group

doi:10.1016/j.jmbbm.2018.01.033

Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices

On behalf of the CranioSafe Group

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Nowadays, personalized medical devices are frequently used for patients. Due to the manufacturing procedure sterilization is required. How different sterilization methods affect the mechanical behavior of these devices is largely unknown. Materials and methods: Three poly(methyl methacrylate) (PMMA) based materials (Vertex Self-Curing, Palacos R+G, and NextDent C&B MFH) were sterilized with different sterilization methods: ethylene oxide, hydrogen peroxide gas plasma, autoclavation, and γ-irradiation. Mechanical properties were determined by testing the flexural strength, flexural modulus, fracture toughness, and impact strength. Results: The flexural strength of all materials was significantly higher after γ-irradiation compared to the control and other sterilization methods, as tested in a wet environment. NextDent C&B MFH showed the highest flexural and impact strength, Palacos R+G showed the highest maximum stress intensity factor and total fracture work. Conclusion: Autoclave sterilization is not suitable for the sterilization of PMMA-based materials. Ethylene oxide, hydrogen peroxide gas plasma, and γ-irradiation appear to be suitable techniques to sterilize PMMA-based personalized medical devices.

Original language	English
Pages (from-to)	168-172
Number of pages	5
Journal	Journal of the Mechanical Behavior of Biomedical Materials
Volume	81
DOIs	https://doi.org/10.1016/j.jmbbm.2018.01.033
Publication status	Published - 1 May 2018

Funding

This research is supported by the Dutch Technology Foundation STW (Project Nr. 14326; CranioSafe), which is part of the Netherlands Organisation for Scientific Research (NWO), and which is partly funded by the Ministry of Economic Affairs. This research is supported by the Dutch Technology Foundation STW (Project Nr. 14326; CranioSafe), which is part of the Netherlands Organisation for Scientific Research (NWO), and which is partly funded by the Ministry of Economic Affairs. We acknowledge the help of Jerzy Hul and his expertise in this field. This research is supported by the Dutch Technology Foundation STW (Project Nr. 14326 ; CranioSafe), which is part of the Netherlands Organisation for Scientific Research (NWO), and which is partly funded by the Ministry of Economic Affairs . We acknowledge the help of Jerzy Hul and his expertise in this field.

Funders	Funder number
Ministerie van Economische Zaken
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Stichting voor de Technische Wetenschappen	14326
Ministry of Economic Affairs

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@article{420e5b9531c24b0db90123b45f3c9205,

title = "Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices",

abstract = "Background: Nowadays, personalized medical devices are frequently used for patients. Due to the manufacturing procedure sterilization is required. How different sterilization methods affect the mechanical behavior of these devices is largely unknown. Materials and methods: Three poly(methyl methacrylate) (PMMA) based materials (Vertex Self-Curing, Palacos R+G, and NextDent C&B MFH) were sterilized with different sterilization methods: ethylene oxide, hydrogen peroxide gas plasma, autoclavation, and γ-irradiation. Mechanical properties were determined by testing the flexural strength, flexural modulus, fracture toughness, and impact strength. Results: The flexural strength of all materials was significantly higher after γ-irradiation compared to the control and other sterilization methods, as tested in a wet environment. NextDent C&B MFH showed the highest flexural and impact strength, Palacos R+G showed the highest maximum stress intensity factor and total fracture work. Conclusion: Autoclave sterilization is not suitable for the sterilization of PMMA-based materials. Ethylene oxide, hydrogen peroxide gas plasma, and γ-irradiation appear to be suitable techniques to sterilize PMMA-based personalized medical devices.",

author = "T.J.A.G. M{\"u}nker and {van de Vijfeijken}, S.E.C.M. and C.S. Mulder and V. Vespasiano and A.G. Becking and C.J. Kleverlaan and {On behalf of the CranioSafe Group} and A.G. Becking and L. Dubois and L.H.E. Karssemakers and D.M.J. Milstein and {van de Vijfeijken}, S.E.C.M. and P.R.A.M. Depauw and F.W.A. Hoefnagels and W.P. Vandertop and C.J. Kleverlaan and T.J.A.G. M{\"u}nker and T.J.J. Maal and E. Nout and M. Riool and S.A.J. Zaat",

year = "2018",

month = may,

day = "1",

doi = "10.1016/j.jmbbm.2018.01.033",

language = "English",

volume = "81",

pages = "168--172",

journal = "Journal of the Mechanical Behavior of Biomedical Materials",

issn = "1751-6161",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices

AU - Münker, T.J.A.G.

AU - van de Vijfeijken, S.E.C.M.

AU - Mulder, C.S.

AU - Vespasiano, V.

AU - Becking, A.G.

AU - Kleverlaan, C.J.

AU - On behalf of the CranioSafe Group

AU - Becking, A.G.

AU - Dubois, L.

AU - Karssemakers, L.H.E.

AU - Milstein, D.M.J.

AU - van de Vijfeijken, S.E.C.M.

AU - Depauw, P.R.A.M.

AU - Hoefnagels, F.W.A.

AU - Vandertop, W.P.

AU - Kleverlaan, C.J.

AU - Münker, T.J.A.G.

AU - Maal, T.J.J.

AU - Nout, E.

AU - Riool, M.

AU - Zaat, S.A.J.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Nowadays, personalized medical devices are frequently used for patients. Due to the manufacturing procedure sterilization is required. How different sterilization methods affect the mechanical behavior of these devices is largely unknown. Materials and methods: Three poly(methyl methacrylate) (PMMA) based materials (Vertex Self-Curing, Palacos R+G, and NextDent C&B MFH) were sterilized with different sterilization methods: ethylene oxide, hydrogen peroxide gas plasma, autoclavation, and γ-irradiation. Mechanical properties were determined by testing the flexural strength, flexural modulus, fracture toughness, and impact strength. Results: The flexural strength of all materials was significantly higher after γ-irradiation compared to the control and other sterilization methods, as tested in a wet environment. NextDent C&B MFH showed the highest flexural and impact strength, Palacos R+G showed the highest maximum stress intensity factor and total fracture work. Conclusion: Autoclave sterilization is not suitable for the sterilization of PMMA-based materials. Ethylene oxide, hydrogen peroxide gas plasma, and γ-irradiation appear to be suitable techniques to sterilize PMMA-based personalized medical devices.

AB - Background: Nowadays, personalized medical devices are frequently used for patients. Due to the manufacturing procedure sterilization is required. How different sterilization methods affect the mechanical behavior of these devices is largely unknown. Materials and methods: Three poly(methyl methacrylate) (PMMA) based materials (Vertex Self-Curing, Palacos R+G, and NextDent C&B MFH) were sterilized with different sterilization methods: ethylene oxide, hydrogen peroxide gas plasma, autoclavation, and γ-irradiation. Mechanical properties were determined by testing the flexural strength, flexural modulus, fracture toughness, and impact strength. Results: The flexural strength of all materials was significantly higher after γ-irradiation compared to the control and other sterilization methods, as tested in a wet environment. NextDent C&B MFH showed the highest flexural and impact strength, Palacos R+G showed the highest maximum stress intensity factor and total fracture work. Conclusion: Autoclave sterilization is not suitable for the sterilization of PMMA-based materials. Ethylene oxide, hydrogen peroxide gas plasma, and γ-irradiation appear to be suitable techniques to sterilize PMMA-based personalized medical devices.

U2 - 10.1016/j.jmbbm.2018.01.033

DO - 10.1016/j.jmbbm.2018.01.033

M3 - Article

SN - 1751-6161

VL - 81

SP - 168

EP - 172

JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

ER -

Effects of sterilization on the mechanical properties of poly(methyl methacrylate) based personalized medical devices

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