Efficiency Efficiency, Diversity, and Complexity with Multicomponent Reactions Efficiency Efficiency, Diversity, and Complexity with Multicomponent Reactions

G. van der Heijden, E. Ruijter, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Multicomponent reactions (MCRs) are versatile syntheses for obtaining structurally diverse sets of complex scaffolds with high efficiency. As such, they can be attractive synthetic tools for the realization of diversity- and/or biology-oriented synthesis design strategies for focused libraries. In this account, we present an overview of our contribution to the design of novel MCRs to access a high level of molecular complexity and diversity. In addition, we demonstrate our biocatalysis/MCR sequences to obtain stereoenriched product scaffolds. 1 Introduction 2 The Build/Couple/Pair Strategy 3 Rational Design of Multicomponent Reactions 3.1 Single Reactant Replacement 3.2 Modular Reaction Sequences 3.3 Conditions-Based Divergence 3.4 The Combination of Multicomponent Reactions 4 Palladium-Catalyzed Isocyanide Reactions 5 The Quest for Stereoselective Multicomponent Reactions 6 Conclusion. © Georg Thieme Verlag Stuttgart - New York.
Original languageEnglish
Pages (from-to)666-68
JournalSynlett
Volume2013
DOIs
Publication statusPublished - 2013

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