Efficient C2 functionalisation of 2H-2-imidazolines

R.S. Bon, N.E. Sprenkels, M.M. Koningstein, R.F. Schmitz, F.J.J. de Kanter, A. Domling, M.B. Groen, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins). © The Royal Society of Chemistry 2008.
Original languageEnglish
Pages (from-to)130-7
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number1
DOIs
Publication statusPublished - 2008

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alkylation
inhibitors
chemistry
analogs
microwaves
oxidation
Alkylation
Microwaves
interactions
Oxidation
2-imidazoline

Cite this

Bon, R. S., Sprenkels, N. E., Koningstein, M. M., Schmitz, R. F., de Kanter, F. J. J., Domling, A., ... Orru, R. V. A. (2008). Efficient C2 functionalisation of 2H-2-imidazolines. Organic and Biomolecular Chemistry, 6(1), 130-7. https://doi.org/10.1039/b713065a
Bon, R.S. ; Sprenkels, N.E. ; Koningstein, M.M. ; Schmitz, R.F. ; de Kanter, F.J.J. ; Domling, A. ; Groen, M.B. ; Orru, R.V.A. / Efficient C2 functionalisation of 2H-2-imidazolines. In: Organic and Biomolecular Chemistry. 2008 ; Vol. 6, No. 1. pp. 130-7.
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Bon, RS, Sprenkels, NE, Koningstein, MM, Schmitz, RF, de Kanter, FJJ, Domling, A, Groen, MB & Orru, RVA 2008, 'Efficient C2 functionalisation of 2H-2-imidazolines' Organic and Biomolecular Chemistry, vol. 6, no. 1, pp. 130-7. https://doi.org/10.1039/b713065a

Efficient C2 functionalisation of 2H-2-imidazolines. / Bon, R.S.; Sprenkels, N.E.; Koningstein, M.M.; Schmitz, R.F.; de Kanter, F.J.J.; Domling, A.; Groen, M.B.; Orru, R.V.A.

In: Organic and Biomolecular Chemistry, Vol. 6, No. 1, 2008, p. 130-7.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Efficient C2 functionalisation of 2H-2-imidazolines

AU - Bon, R.S.

AU - Sprenkels, N.E.

AU - Koningstein, M.M.

AU - Schmitz, R.F.

AU - de Kanter, F.J.J.

AU - Domling, A.

AU - Groen, M.B.

AU - Orru, R.V.A.

PY - 2008

Y1 - 2008

N2 - Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins). © The Royal Society of Chemistry 2008.

AB - Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins). © The Royal Society of Chemistry 2008.

U2 - 10.1039/b713065a

DO - 10.1039/b713065a

M3 - Article

VL - 6

SP - 130

EP - 137

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 1

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Bon RS, Sprenkels NE, Koningstein MM, Schmitz RF, de Kanter FJJ, Domling A et al. Efficient C2 functionalisation of 2H-2-imidazolines. Organic and Biomolecular Chemistry. 2008;6(1):130-7. https://doi.org/10.1039/b713065a