Efficient C2 functionalisation of 2H-2-imidazolines

R.S. Bon, N.E. Sprenkels, M.M. Koningstein, R.F. Schmitz, F.J.J. de Kanter, A. Domling, M.B. Groen, R.V.A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins). © The Royal Society of Chemistry 2008.
Original languageEnglish
Pages (from-to)130-7
JournalOrganic and Biomolecular Chemistry
Volume6
Issue number1
DOIs
Publication statusPublished - 2008

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