Efficient C2 functionalisation of 2H-2-imidazolines

R.S. Bon; N.E. Sprenkels; M.M. Koningstein; R.F. Schmitz; F.J.J. de Kanter; A. Domling; M.B. Groen; R.V.A. Orru

doi:10.1039/b713065a

Efficient C2 functionalisation of 2H-2-imidazolines

R.S. Bon, N.E. Sprenkels, M.M. Koningstein, R.F. Schmitz, F.J.J. de Kanter, A. Domling, M.B. Groen, R.V.A. Orru

Organic Chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins). © The Royal Society of Chemistry 2008.

Original language	English
Pages (from-to)	130-7
Journal	Organic and Biomolecular Chemistry
Volume	6
Issue number	1
DOIs	https://doi.org/10.1039/b713065a
Publication status	Published - 2008

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title = "Efficient C2 functionalisation of 2H-2-imidazolines",

abstract = "Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins). {\textcopyright} The Royal Society of Chemistry 2008.",

author = "R.S. Bon and N.E. Sprenkels and M.M. Koningstein and R.F. Schmitz and {de Kanter}, F.J.J. and A. Domling and M.B. Groen and R.V.A. Orru",

year = "2008",

doi = "10.1039/b713065a",

language = "English",

volume = "6",

pages = "130--7",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Efficient C2 functionalisation of 2H-2-imidazolines

AU - Bon, R.S.

AU - Sprenkels, N.E.

AU - Koningstein, M.M.

AU - Schmitz, R.F.

AU - de Kanter, F.J.J.

AU - Domling, A.

AU - Groen, M.B.

AU - Orru, R.V.A.

PY - 2008

Y1 - 2008

N2 - Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins). © The Royal Society of Chemistry 2008.

AB - Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins). © The Royal Society of Chemistry 2008.

U2 - 10.1039/b713065a

DO - 10.1039/b713065a

M3 - Article

VL - 6

SP - 130

EP - 137

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 1

ER -

Efficient C2 functionalisation of 2H-2-imidazolines

Abstract

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