Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation

E. Gelens; F.J.J. De Kanter; R.F. Schmitz; L.A. Sliedregt; B.J. Van Steen; C.G. Kruse; R. Leurs; M.B. Groen; R.V.A. Orru

doi:10.1007/s11030-006-8695-3

Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation

E. Gelens
, F.J.J. De Kanter
, R.F. Schmitz
, L.A. Sliedregt
, B.J. Van Steen
, C.G. Kruse
, R. Leurs
, M.B. Groen
, R.V.A. Orru

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Optimization of Radziszewski's four-component reaction employing a microwave-assisted protocol, led to a small library of 48 imidazoles with a success rate of 65% (conversion >45%). All three diversity points of the four-component reaction were varied. Aromatic and aliphatic inputs were successfully implemented and mono-, di-, tri- and tetrasubstituted imidazoles with various substitution patterns were synthesized. Furthermore, unsymmetrical diketones could successfully be used which improved the intrinsic diversity of the method significantly. If the unsymmetrical diketone 1,2-phenylpropanedione (R

Original language	English
Pages (from-to)	17-22
Journal	Molecular Diversity
Volume	10
Issue number	1
DOIs	https://doi.org/10.1007/s11030-006-8695-3
Publication status	Published - 2006

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AU - Gelens, E.

AU - De Kanter, F.J.J.

AU - Schmitz, R.F.

AU - Sliedregt, L.A.

AU - Van Steen, B.J.

AU - Kruse, C.G.

AU - Leurs, R.

AU - Groen, M.B.

AU - Orru, R.V.A.

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Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation

Abstract

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