Efficient one-pot three-component synthesis of novel spiro(indoline-3,7′-thiazolo[3,2-a]pyrimidine) derivatives

Zahra Jamshidi; Abbas Ali Esmaeili; Joel T. Mague

doi:10.3184/174751916X14664437565774

Efficient one-pot three-component synthesis of novel spiro(indoline-3,7′-thiazolo[3,2-a]pyrimidine) derivatives

Zahra Jamshidi, Abbas Ali Esmaeili^*, Joel T. Mague

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A practical, simple and efficient method for the synthesis of thiazolo[3,2-a]pyrimidine-fused spirooxindoles by a three-component reaction of isatins, malononitrile and 2-amino-2-thiazoline in the presence of CuI as catalyst in ethylene glycol is reported.

Original language	English
Pages (from-to)	471-474
Number of pages	4
Journal	Journal of Chemical Research
Volume	40
Issue number	8
DOIs	https://doi.org/10.3184/174751916X14664437565774
Publication status	Published - 1 Aug 2016
Externally published	Yes

Keywords

2-amino-2-thiazoline
Ethyl cyanoacetate
Malononitrile
Multi-component reaction
Spirooxindoles
Thiazolo[3,2-a]pyrimidine

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10.3184/174751916X14664437565774

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title = "Efficient one-pot three-component synthesis of novel spiro(indoline-3,7′-thiazolo[3,2-a]pyrimidine) derivatives",

abstract = "A practical, simple and efficient method for the synthesis of thiazolo[3,2-a]pyrimidine-fused spirooxindoles by a three-component reaction of isatins, malononitrile and 2-amino-2-thiazoline in the presence of CuI as catalyst in ethylene glycol is reported.",

keywords = "2-amino-2-thiazoline, Ethyl cyanoacetate, Malononitrile, Multi-component reaction, Spirooxindoles, Thiazolo[3,2-a]pyrimidine",

author = "Zahra Jamshidi and Esmaeili, {Abbas Ali} and Mague, {Joel T.}",

year = "2016",

month = aug,

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doi = "10.3184/174751916X14664437565774",

language = "English",

volume = "40",

pages = "471--474",

journal = "Journal of Chemical Research",

issn = "1747-5198",

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AU - Jamshidi, Zahra

AU - Esmaeili, Abbas Ali

AU - Mague, Joel T.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - A practical, simple and efficient method for the synthesis of thiazolo[3,2-a]pyrimidine-fused spirooxindoles by a three-component reaction of isatins, malononitrile and 2-amino-2-thiazoline in the presence of CuI as catalyst in ethylene glycol is reported.

AB - A practical, simple and efficient method for the synthesis of thiazolo[3,2-a]pyrimidine-fused spirooxindoles by a three-component reaction of isatins, malononitrile and 2-amino-2-thiazoline in the presence of CuI as catalyst in ethylene glycol is reported.

KW - 2-amino-2-thiazoline

KW - Ethyl cyanoacetate

KW - Malononitrile

KW - Multi-component reaction

KW - Spirooxindoles

KW - Thiazolo[3,2-a]pyrimidine

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JO - Journal of Chemical Research

JF - Journal of Chemical Research

IS - 8

ER -

Efficient one-pot three-component synthesis of novel spiro(indoline-3,7′-thiazolo[3,2-a]pyrimidine) derivatives

Abstract

Keywords

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