Abstract
The Illumina Infinium EPIC BeadChip is a new high-throughput array for DNA methylation analysis, extending the earlier 450k array by over 400 000 new sites. Previously, a method named eFORGE was developed to provide insights into cell type-specific and cell-composition effects for 450k data. Here, we present a significantly updated and improved version of eFORGE that can analyze both EPIC and 450k array data. New features include analysis of chromatin states, transcription factor motifs and DNase I footprints, providing tools for epigenome-wide association study interpretation and epigenome editing.
Original language | English |
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Pages (from-to) | 4767-4769 |
Number of pages | 3 |
Journal | Bioinformatics |
Volume | 35 |
Issue number | 22 |
DOIs | |
Publication status | Published - 1 Nov 2019 |
Funding
C.E.B. was supported by a fellowship from the EU-FP7 project EpiTrain [316758]. Research in S.B.’s group was supported by the Wellcome Trust [99148]; Royal Society Wolfson Research Merit Award [WM100023] and EU-FP7 projects EpiTrain [316758]; EPIGENESYS [257082]; and BLUEPRINT [282510].
Funders | Funder number |
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EU-FP7 | |
Wellcome Trust | 99148 |
Seventh Framework Programme | 257082, 316758, 282510 |