EIF4G1 mutations do not cause Parkinson's disease

N. Nichols, J.M. Bras, D.G. Hernandez, I.E. Jansen, S. Lesage, S. Lubbe, A.B. Singleton

    Research output: Contribution to JournalArticleAcademicpeer-review


    EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.
    Original languageEnglish
    Pages (from-to)2444.e1-2444.e4
    JournalNeurobiology of Aging
    Issue number8
    Publication statusPublished - 2015


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