EIF4G1 mutations do not cause Parkinson's disease

N. Nichols; J.M. Bras; D.G. Hernandez; I.E. Jansen; S. Lesage; S. Lubbe; A.B. Singleton

doi:10.1016/j.neurobiolaging.2015.04.017

EIF4G1 mutations do not cause Parkinson's disease

N. Nichols, J.M. Bras, D.G. Hernandez, I.E. Jansen, S. Lesage, S. Lubbe, A.B. Singleton

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.

Original language	English
Pages (from-to)	2444.e1-2444.e4
Journal	Neurobiology of Aging
Volume	36
Issue number	8
DOIs	https://doi.org/10.1016/j.neurobiolaging.2015.04.017
Publication status	Published - 2015

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10.1016/j.neurobiolaging.2015.04.017

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title = "EIF4G1 mutations do not cause Parkinson's disease",

abstract = "EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.",

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AU - Bras, J.M.

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AU - Jansen, I.E.

AU - Lesage, S.

AU - Lubbe, S.

AU - Singleton, A.B.

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AB - EIF4G1 mutations were previously reported as a cause of Parkinson's disease (PD). As a result of this finding, considerable work has been performed to test this idea and to examine the functional role of eukaryotic translation initiation factor 4-gamma in the pathogenic process underlying PD. Here, we show that the originally described mutation is likely a rare benign variant. We tested this variant in a very large series of subjects and show that it is more frequent in controls than cases. We argue here that this infers that EIF4G1 mutations are not related to PD.

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DO - 10.1016/j.neurobiolaging.2015.04.017

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JO - Neurobiology of Aging

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ER -

EIF4G1 mutations do not cause Parkinson's disease

Abstract

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