Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

G. Zhai, A. Teumer, L. Stolk, J.R. Perry, L. Vandenput, A.D. Coviello, A. Koster, J.T. Bell, S. Bhasin, J. Eriksson, A. Eriksson, F. Ernst, L. Ferrucci, T.M. Frayling, D. Glass, E. Grundberg, R. Haring, A.K. Hedman, A. Hofman, D.P. KielH.K. Kroemer, Y. Liu, K.L. Lunetta, M. Maggio, M. Lorentzon, M. Mangino, D. Melzer, I. Miljkovic, A. Nica, B.W.J.H. Penninx, R.S. Vasan, F. Rivadeneira, K.S. Small, N. Soranzo, A. G. Uitterlinden, H. Voelzke, S.G. Wilson, L. Xi, W.V. Zhuang, T.B. Harris, J.M. Murabito, C. Ohlsson, A. Murray, F.H. de Jong, T.D. Spector, H. Wallaschofski

    Research output: Contribution to JournalArticleAcademicpeer-review

    170 Downloads (Pure)

    Abstract

    Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10
    Original languageEnglish
    Article numbere1002025
    JournalPLoS Genetics
    Volume7
    Issue number4
    DOIs
    Publication statusPublished - 2011

    Fingerprint

    Dive into the research topics of 'Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms'. Together they form a unique fingerprint.

    Cite this