Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

G. Zhai; A. Teumer; L. Stolk; J.R. Perry; L. Vandenput; A.D. Coviello; A. Koster; J.T. Bell; S. Bhasin; J. Eriksson; A. Eriksson; F. Ernst; L. Ferrucci; T.M. Frayling; D. Glass; E. Grundberg; R. Haring; A.K. Hedman; A. Hofman; D.P. Kiel; H.K. Kroemer; Y. Liu; K.L. Lunetta; M. Maggio; M. Lorentzon; M. Mangino; D. Melzer; I. Miljkovic; A. Nica; B.W.J.H. Penninx; R.S. Vasan; F. Rivadeneira; K.S. Small; N. Soranzo; A. G. Uitterlinden; H. Voelzke; S.G. Wilson; L. Xi; W.V. Zhuang; T.B. Harris; J.M. Murabito; C. Ohlsson; A. Murray; F.H. de Jong; T.D. Spector; H. Wallaschofski

doi:10.1371/journal.pgen.1002025

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

G. Zhai, A. Teumer, L. Stolk, J.R. Perry, L. Vandenput, A.D. Coviello, A. Koster, J.T. Bell, S. Bhasin, J. Eriksson, A. Eriksson, F. Ernst, L. Ferrucci, T.M. Frayling, D. Glass, E. Grundberg, R. Haring, A.K. Hedman, A. Hofman, D.P. KielH.K. Kroemer, Y. Liu, K.L. Lunetta, M. Maggio, M. Lorentzon, M. Mangino, D. Melzer, I. Miljkovic, A. Nica, B.W.J.H. Penninx, R.S. Vasan, F. Rivadeneira, K.S. Small, N. Soranzo, A. G. Uitterlinden, H. Voelzke, S.G. Wilson, L. Xi, W.V. Zhuang, T.B. Harris, J.M. Murabito, C. Ohlsson, A. Murray, F.H. de Jong, T.D. Spector, H. Wallaschofski

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Abstract

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10

Original language	English
Article number	e1002025
Journal	PLoS Genetics
Volume	7
Issue number	4
DOIs	https://doi.org/10.1371/journal.pgen.1002025
Publication status	Published - 2011

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Zhai, G., Teumer, A., Stolk, L., Perry, J. R., Vandenput, L., Coviello, A. D., Koster, A., Bell, J. T., Bhasin, S., Eriksson, J., Eriksson, A., Ernst, F., Ferrucci, L., Frayling, T. M., Glass, D., Grundberg, E., Haring, R., Hedman, A. K., Hofman, A., ... Wallaschofski, H. (2011). Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genetics, 7(4), [e1002025]. https://doi.org/10.1371/journal.pgen.1002025

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title = "Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms",

abstract = "Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10",

author = "G. Zhai and A. Teumer and L. Stolk and J.R. Perry and L. Vandenput and A.D. Coviello and A. Koster and J.T. Bell and S. Bhasin and J. Eriksson and A. Eriksson and F. Ernst and L. Ferrucci and T.M. Frayling and D. Glass and E. Grundberg and R. Haring and A.K. Hedman and A. Hofman and D.P. Kiel and H.K. Kroemer and Y. Liu and K.L. Lunetta and M. Maggio and M. Lorentzon and M. Mangino and D. Melzer and I. Miljkovic and A. Nica and B.W.J.H. Penninx and R.S. Vasan and F. Rivadeneira and K.S. Small and N. Soranzo and Uitterlinden, {A. G.} and H. Voelzke and S.G. Wilson and L. Xi and W.V. Zhuang and T.B. Harris and J.M. Murabito and C. Ohlsson and A. Murray and {de Jong}, F.H. and T.D. Spector and H. Wallaschofski",

year = "2011",

doi = "10.1371/journal.pgen.1002025",

language = "English",

volume = "7",

journal = "PLoS Genetics",

issn = "1553-7390",

publisher = "Public Library of Science",

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Zhai, G, Teumer, A, Stolk, L, Perry, JR, Vandenput, L, Coviello, AD, Koster, A, Bell, JT, Bhasin, S, Eriksson, J, Eriksson, A, Ernst, F, Ferrucci, L, Frayling, TM, Glass, D, Grundberg, E, Haring, R, Hedman, AK, Hofman, A, Kiel, DP, Kroemer, HK, Liu, Y, Lunetta, KL, Maggio, M, Lorentzon, M, Mangino, M, Melzer, D, Miljkovic, I, Nica, A, Penninx, BWJH, Vasan, RS, Rivadeneira, F, Small, KS, Soranzo, N, Uitterlinden, AG, Voelzke, H, Wilson, SG, Xi, L, Zhuang, WV, Harris, TB, Murabito, JM, Ohlsson, C, Murray, A, de Jong, FH, Spector, TD & Wallaschofski, H 2011, 'Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms', PLoS Genetics, vol. 7, no. 4, e1002025. https://doi.org/10.1371/journal.pgen.1002025

TY - JOUR

T1 - Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

AU - Zhai, G.

AU - Teumer, A.

AU - Stolk, L.

AU - Perry, J.R.

AU - Vandenput, L.

AU - Coviello, A.D.

AU - Koster, A.

AU - Bell, J.T.

AU - Bhasin, S.

AU - Eriksson, J.

AU - Eriksson, A.

AU - Ernst, F.

AU - Ferrucci, L.

AU - Frayling, T.M.

AU - Glass, D.

AU - Grundberg, E.

AU - Haring, R.

AU - Hedman, A.K.

AU - Hofman, A.

AU - Kiel, D.P.

AU - Kroemer, H.K.

AU - Liu, Y.

AU - Lunetta, K.L.

AU - Maggio, M.

AU - Lorentzon, M.

AU - Mangino, M.

AU - Melzer, D.

AU - Miljkovic, I.

AU - Nica, A.

AU - Penninx, B.W.J.H.

AU - Vasan, R.S.

AU - Rivadeneira, F.

AU - Small, K.S.

AU - Soranzo, N.

AU - Uitterlinden, A. G.

AU - Voelzke, H.

AU - Wilson, S.G.

AU - Xi, L.

AU - Zhuang, W.V.

AU - Harris, T.B.

AU - Murabito, J.M.

AU - Ohlsson, C.

AU - Murray, A.

AU - de Jong, F.H.

AU - Spector, T.D.

AU - Wallaschofski, H.

PY - 2011

Y1 - 2011

N2 - Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10

AB - Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10

U2 - 10.1371/journal.pgen.1002025

DO - 10.1371/journal.pgen.1002025

M3 - Article

SN - 1553-7390

VL - 7

JO - PLoS Genetics

JF - PLoS Genetics

IS - 4

M1 - e1002025

ER -

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

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