Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

Guangju Zhai; Alexander Teumer; Lisette Stolk; John R. B. Perry; Liesbeth Vandenput; Andrea D. Coviello; Annemarie Koster; Jordana T. Bell; Shalender Bhasin; Joel Eriksson; Anna Eriksson; Florian Ernst; Luigi Ferrucci; Timothy M. Frayling; Daniel Glass; Elin Grundberg; Robin Haring; Åsa K. HedmanÅ; Albert Hofman; Douglas P. Kiel; Heyo K. Kroemer; Yongmei Liu; Kathryn L. Lunetta; Marcello Maggio; Mattias Lorentzon; Massimo Mangino; David Melzer; Iva Miljkovic; Alexandra Nica; Brenda W. J. H. Penninx; Ramachandran S. Vasan; Fernando Rivadeneira; Kerrin S. Small; Nicole Soranzo; André G. Uitterlinden; Henry Völzke; Scott G. Wilson; Li Xi; Wei Vivian Zhuang; Tamara B. Harris; Joanne M. Murabito; Claes Ohlsson; Anna Murray; Frank H. de Jong; Tim D. Spector; Henri Wallaschofski

doi:10.1371/journal.pgen.1002025

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

Guangju Zhai
, Alexander Teumer
, Lisette Stolk
, John R. B. Perry
, Liesbeth Vandenput
, Andrea D. Coviello
, Annemarie Koster
, Jordana T. Bell
, Shalender Bhasin
, Joel Eriksson
, Anna Eriksson
, Florian Ernst
, Luigi Ferrucci
, Timothy M. Frayling
, Daniel Glass
, Elin Grundberg
, Robin Haring
, Åsa K. HedmanÅ
, Albert Hofman
, Douglas P. Kiel

Heyo K. Kroemer, Yongmei Liu, Kathryn L. Lunetta, Marcello Maggio, Mattias Lorentzon, Massimo Mangino, David Melzer, Iva Miljkovic, Alexandra Nica, Brenda W. J. H. Penninx, Ramachandran S. Vasan, Fernando Rivadeneira, Kerrin S. Small, Nicole Soranzo, André G. Uitterlinden, Henry Völzke, Scott G. Wilson, Li Xi, Wei Vivian Zhuang, Tamara B. Harris, Joanne M. Murabito, Claes Ohlsson, Anna Murray, Frank H. de Jong, Tim D. Spector, Henri Wallaschofski

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Abstract

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10

Original language	English
Article number	e1002025
Journal	PLoS Genetics
Volume	7
Issue number	4
DOIs	https://doi.org/10.1371/journal.pgen.1002025
Publication status	Published - 2011
Externally published	Yes

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Zhai, G., Teumer, A., Stolk, L., Perry, J. R. B., Vandenput, L., Coviello, A. D., Koster, A., Bell, J. T., Bhasin, S., Eriksson, J., Eriksson, A., Ernst, F., Ferrucci, L., Frayling, T. M., Glass, D., Grundberg, E., Haring, R., HedmanÅ, Å. K., Hofman, A., ... Wallaschofski, H. (2011). Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genetics, 7(4), Article e1002025. https://doi.org/10.1371/journal.pgen.1002025

@article{9f7c22c456b143cc83fa3950313a96a7,

title = "Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms",

abstract = "Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10",

author = "Guangju Zhai and Alexander Teumer and Lisette Stolk and Perry, \{John R. B.\} and Liesbeth Vandenput and Coviello, \{Andrea D.\} and Annemarie Koster and Bell, \{Jordana T.\} and Shalender Bhasin and Joel Eriksson and Anna Eriksson and Florian Ernst and Luigi Ferrucci and Frayling, \{Timothy M.\} and Daniel Glass and Elin Grundberg and Robin Haring and Hedman{\AA}, \{{\AA}sa K.\} and Albert Hofman and Kiel, \{Douglas P.\} and Kroemer, \{Heyo K.\} and Yongmei Liu and Lunetta, \{Kathryn L.\} and Marcello Maggio and Mattias Lorentzon and Massimo Mangino and David Melzer and Iva Miljkovic and Alexandra Nica and Penninx, \{Brenda W. J. H.\} and Vasan, \{Ramachandran S.\} and Fernando Rivadeneira and Small, \{Kerrin S.\} and Nicole Soranzo and Uitterlinden, \{Andr{\'e} G.\} and Henry V{\"o}lzke and Wilson, \{Scott G.\} and Li Xi and Zhuang, \{Wei Vivian\} and Harris, \{Tamara B.\} and Murabito, \{Joanne M.\} and Claes Ohlsson and Anna Murray and \{de Jong\}, \{Frank H.\} and Spector, \{Tim D.\} and Henri Wallaschofski",

year = "2011",

doi = "10.1371/journal.pgen.1002025",

language = "English",

volume = "7",

journal = "PLoS Genetics",

issn = "1553-7390",

publisher = "Public Library of Science",

number = "4",

}

Zhai, G, Teumer, A, Stolk, L, Perry, JRB, Vandenput, L, Coviello, AD, Koster, A, Bell, JT, Bhasin, S, Eriksson, J, Eriksson, A, Ernst, F, Ferrucci, L, Frayling, TM, Glass, D, Grundberg, E, Haring, R, HedmanÅ, ÅK, Hofman, A, Kiel, DP, Kroemer, HK, Liu, Y, Lunetta, KL, Maggio, M, Lorentzon, M, Mangino, M, Melzer, D, Miljkovic, I, Nica, A, Penninx, BWJH, Vasan, RS, Rivadeneira, F, Small, KS, Soranzo, N, Uitterlinden, AG, Völzke, H, Wilson, SG, Xi, L, Zhuang, WV, Harris, TB, Murabito, JM, Ohlsson, C, Murray, A, de Jong, FH, Spector, TD & Wallaschofski, H 2011, 'Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms', PLoS Genetics, vol. 7, no. 4, e1002025. https://doi.org/10.1371/journal.pgen.1002025

TY - JOUR

T1 - Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

AU - Zhai, Guangju

AU - Teumer, Alexander

AU - Stolk, Lisette

AU - Perry, John R. B.

AU - Vandenput, Liesbeth

AU - Coviello, Andrea D.

AU - Koster, Annemarie

AU - Bell, Jordana T.

AU - Bhasin, Shalender

AU - Eriksson, Joel

AU - Eriksson, Anna

AU - Ernst, Florian

AU - Ferrucci, Luigi

AU - Frayling, Timothy M.

AU - Glass, Daniel

AU - Grundberg, Elin

AU - Haring, Robin

AU - HedmanÅ, Åsa K.

AU - Hofman, Albert

AU - Kiel, Douglas P.

AU - Kroemer, Heyo K.

AU - Liu, Yongmei

AU - Lunetta, Kathryn L.

AU - Maggio, Marcello

AU - Lorentzon, Mattias

AU - Mangino, Massimo

AU - Melzer, David

AU - Miljkovic, Iva

AU - Nica, Alexandra

AU - Penninx, Brenda W. J. H.

AU - Vasan, Ramachandran S.

AU - Rivadeneira, Fernando

AU - Small, Kerrin S.

AU - Soranzo, Nicole

AU - Uitterlinden, André G.

AU - Völzke, Henry

AU - Wilson, Scott G.

AU - Xi, Li

AU - Zhuang, Wei Vivian

AU - Harris, Tamara B.

AU - Murabito, Joanne M.

AU - Ohlsson, Claes

AU - Murray, Anna

AU - de Jong, Frank H.

AU - Spector, Tim D.

AU - Wallaschofski, Henri

PY - 2011

Y1 - 2011

N2 - Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10

AB - Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development of common age-related diseases or diminished longevity. We conducted a meta-analysis of genome-wide association data with 14,846 individuals and identified eight independent common SNPs associated with serum DHEAS concentrations. Genes at or near the identified loci include ZKSCAN5 (rs11761528; p = 3.15×10

U2 - 10.1371/journal.pgen.1002025

DO - 10.1371/journal.pgen.1002025

M3 - Article

SN - 1553-7390

VL - 7

JO - PLoS Genetics

JF - PLoS Genetics

IS - 4

M1 - e1002025

ER -

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

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