Elasticity in Ionically Cross-Linked Neurofilament Networks

N.Y. Yao; C.P. Broedersz; Y.C. Lin; K. E. Kasza; F.C. MacKintosh; D. A. Weitz

doi:10.1016/j.bpj.2010.01.062

Elasticity in Ionically Cross-Linked Neurofilament Networks

N.Y. Yao, C.P. Broedersz, Y.C. Lin, K. E. Kasza, F.C. MacKintosh, D. A. Weitz

LaserLaB - Molecular Biophysics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Neurofilaments are found in abundance in the cytoskeleton of neurons, where they act as an intracellular framework protecting the neuron from external stresses. To elucidate the nature of the mechanical properties that provide this protection, we measure the linear and nonlinear viscoelastic properties of networks of neurofilaments. These networks are soft solids that exhibit dramatic strain stiffening above critical strains of 30-70%. Surprisingly, divalent ions such as Mg

Original language	English
Pages (from-to)	2147-2153
Number of pages	7
Journal	Biophysical Journal
Volume	98
Issue number	10
DOIs	https://doi.org/10.1016/j.bpj.2010.01.062
Publication status	Published - 2010

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10.1016/j.bpj.2010.01.062

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title = "Elasticity in Ionically Cross-Linked Neurofilament Networks",

abstract = "Neurofilaments are found in abundance in the cytoskeleton of neurons, where they act as an intracellular framework protecting the neuron from external stresses. To elucidate the nature of the mechanical properties that provide this protection, we measure the linear and nonlinear viscoelastic properties of networks of neurofilaments. These networks are soft solids that exhibit dramatic strain stiffening above critical strains of 30-70%. Surprisingly, divalent ions such as Mg",

author = "N.Y. Yao and C.P. Broedersz and Y.C. Lin and Kasza, {K. E.} and F.C. MacKintosh and Weitz, {D. A.}",

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AU - Yao, N.Y.

AU - Broedersz, C.P.

AU - Lin, Y.C.

AU - Kasza, K. E.

AU - MacKintosh, F.C.

AU - Weitz, D. A.

PY - 2010

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N2 - Neurofilaments are found in abundance in the cytoskeleton of neurons, where they act as an intracellular framework protecting the neuron from external stresses. To elucidate the nature of the mechanical properties that provide this protection, we measure the linear and nonlinear viscoelastic properties of networks of neurofilaments. These networks are soft solids that exhibit dramatic strain stiffening above critical strains of 30-70%. Surprisingly, divalent ions such as Mg

AB - Neurofilaments are found in abundance in the cytoskeleton of neurons, where they act as an intracellular framework protecting the neuron from external stresses. To elucidate the nature of the mechanical properties that provide this protection, we measure the linear and nonlinear viscoelastic properties of networks of neurofilaments. These networks are soft solids that exhibit dramatic strain stiffening above critical strains of 30-70%. Surprisingly, divalent ions such as Mg

U2 - 10.1016/j.bpj.2010.01.062

DO - 10.1016/j.bpj.2010.01.062

M3 - Article

SN - 0006-3495

VL - 98

SP - 2147

EP - 2153

JO - Biophysical Journal

JF - Biophysical Journal

IS - 10

ER -

Elasticity in Ionically Cross-Linked Neurofilament Networks

Abstract

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