Elevated C-reactive protein levels in overweight and obese adults 1

M Visser, L M Bouter, G M McQuillan, M H Wener, T B Harris

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

CONTEXT: Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat. OBJECTIVE: To test whether overweight and obesity are associated with low-grade systemic inflammation as measured by serum C-reactive protein (CRP) level. DESIGN AND SETTING: The Third National Health and Nutrition Examination Survey, representative of the US population from 1988 to 1994. PARTICIPANTS: A total of 16616 men and nonpregnant women aged 17 years or older. MAIN OUTCOME MEASURES: Elevated CRP level of 0.22 mg/dL or more and a more stringent clinically raised CRP level of more than 1.00 mg/dL. RESULTS: Elevated CRP levels and clinically raised CRP levels were present in 27.6% and 6.7% of the population, respectively. Both overweight (body mass index [BMI], 25-29.9 kg/m2) and obese (BMI, > or =30 kg/m2) persons were more likely to have elevated CRP levels than their normal-weight counterparts (BMI,
Original languageEnglish
Pages (from-to)2131-2135
Number of pages5
JournalJAMA
Volume282
Issue number0098-7484 (Print)
Publication statusPublished - 8 Dec 1999

Keywords

  • 1
  • 6
  • ADIPOSE-TISSUE
  • Adipose
  • Adipose tissue
  • Adult
  • Aged
  • Arthritis,Rheumatoid
  • Article
  • Body Fat
  • Body Mass Index
  • C Reactive Protein
  • C-Reactive Protein
  • Cardiovascular Diseases
  • Cardiovascular disease
  • Diabetes Complications
  • Diabetes Mellitus
  • Faculty
  • Female
  • Health
  • Health Status
  • Health Surveys
  • Human
  • Human adipose tissue
  • Inflammation
  • Interleukin 6
  • Interleukin-6
  • Logistic Models
  • MASS
  • Male
  • Medicine
  • Mellitus
  • Middle Aged
  • Nutrition
  • Obese
  • Obesity
  • Odds Ratio
  • Overweight
  • Population
  • Research
  • Serum
  • Smoking
  • Tissue
  • Women
  • Young Adult
  • adults
  • analysis
  • blood
  • body mass
  • complications
  • cytokine
  • diabetes
  • disease
  • estrogen
  • fat
  • humans
  • immunology
  • men
  • metabolism
  • netherlands
  • ob-2.4.10
  • protein

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  • Cite this

    Visser, M., Bouter, L. M., McQuillan, G. M., Wener, M. H., & Harris, T. B. (1999). Elevated C-reactive protein levels in overweight and obese adults 1. JAMA, 282(0098-7484 (Print)), 2131-2135.