Elevated C-reactive protein levels in overweight and obese adults 1

M Visser; L M Bouter; G M McQuillan; M H Wener; T B Harris

Elevated C-reactive protein levels in overweight and obese adults 1

M Visser, L M Bouter, G M McQuillan, M H Wener, T B Harris

Nutrition and Health

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

CONTEXT: Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat. OBJECTIVE: To test whether overweight and obesity are associated with low-grade systemic inflammation as measured by serum C-reactive protein (CRP) level. DESIGN AND SETTING: The Third National Health and Nutrition Examination Survey, representative of the US population from 1988 to 1994. PARTICIPANTS: A total of 16616 men and nonpregnant women aged 17 years or older. MAIN OUTCOME MEASURES: Elevated CRP level of 0.22 mg/dL or more and a more stringent clinically raised CRP level of more than 1.00 mg/dL. RESULTS: Elevated CRP levels and clinically raised CRP levels were present in 27.6% and 6.7% of the population, respectively. Both overweight (body mass index [BMI], 25-29.9 kg/m2) and obese (BMI, > or =30 kg/m2) persons were more likely to have elevated CRP levels than their normal-weight counterparts (BMI,

Original language	English
Pages (from-to)	2131-2135
Number of pages	5
Journal	JAMA
Volume	282
Issue number	0098-7484 (Print)
Publication status	Published - 8 Dec 1999

Keywords

1
6
ADIPOSE-TISSUE
Adipose
Adipose tissue
Adult
Aged
Arthritis,Rheumatoid
Article
Body Fat
Body Mass Index
C Reactive Protein
C-Reactive Protein
Cardiovascular Diseases
Cardiovascular disease
Diabetes Complications
Diabetes Mellitus
Faculty
Female
Health
Health Status
Health Surveys
Human
Human adipose tissue
Inflammation
Interleukin 6
Interleukin-6
Logistic Models
MASS
Male
Medicine
Mellitus
Middle Aged
Nutrition
Obese
Obesity
Odds Ratio
Overweight
Population
Research
Serum
Smoking
Tissue
Women
Young Adult
adults
analysis
blood
body mass
complications
cytokine
diabetes
disease
estrogen
fat
humans
immunology
men
metabolism
netherlands
ob-2.4.10
protein

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "CONTEXT: Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat. OBJECTIVE: To test whether overweight and obesity are associated with low-grade systemic inflammation as measured by serum C-reactive protein (CRP) level. DESIGN AND SETTING: The Third National Health and Nutrition Examination Survey, representative of the US population from 1988 to 1994. PARTICIPANTS: A total of 16616 men and nonpregnant women aged 17 years or older. MAIN OUTCOME MEASURES: Elevated CRP level of 0.22 mg/dL or more and a more stringent clinically raised CRP level of more than 1.00 mg/dL. RESULTS: Elevated CRP levels and clinically raised CRP levels were present in 27.6% and 6.7% of the population, respectively. Both overweight (body mass index [BMI], 25-29.9 kg/m2) and obese (BMI, > or =30 kg/m2) persons were more likely to have elevated CRP levels than their normal-weight counterparts (BMI, ",

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author = "M Visser and Bouter, {L M} and McQuillan, {G M} and Wener, {M H} and Harris, {T B}",

year = "1999",

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language = "English",

volume = "282",

pages = "2131--2135",

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T1 - Elevated C-reactive protein levels in overweight and obese adults 1

AU - Visser, M

AU - Bouter, L M

AU - McQuillan, G M

AU - Wener, M H

AU - Harris, T B

PY - 1999/12/8

Y1 - 1999/12/8

N2 - CONTEXT: Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat. OBJECTIVE: To test whether overweight and obesity are associated with low-grade systemic inflammation as measured by serum C-reactive protein (CRP) level. DESIGN AND SETTING: The Third National Health and Nutrition Examination Survey, representative of the US population from 1988 to 1994. PARTICIPANTS: A total of 16616 men and nonpregnant women aged 17 years or older. MAIN OUTCOME MEASURES: Elevated CRP level of 0.22 mg/dL or more and a more stringent clinically raised CRP level of more than 1.00 mg/dL. RESULTS: Elevated CRP levels and clinically raised CRP levels were present in 27.6% and 6.7% of the population, respectively. Both overweight (body mass index [BMI], 25-29.9 kg/m2) and obese (BMI, > or =30 kg/m2) persons were more likely to have elevated CRP levels than their normal-weight counterparts (BMI,

AB - CONTEXT: Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat. OBJECTIVE: To test whether overweight and obesity are associated with low-grade systemic inflammation as measured by serum C-reactive protein (CRP) level. DESIGN AND SETTING: The Third National Health and Nutrition Examination Survey, representative of the US population from 1988 to 1994. PARTICIPANTS: A total of 16616 men and nonpregnant women aged 17 years or older. MAIN OUTCOME MEASURES: Elevated CRP level of 0.22 mg/dL or more and a more stringent clinically raised CRP level of more than 1.00 mg/dL. RESULTS: Elevated CRP levels and clinically raised CRP levels were present in 27.6% and 6.7% of the population, respectively. Both overweight (body mass index [BMI], 25-29.9 kg/m2) and obese (BMI, > or =30 kg/m2) persons were more likely to have elevated CRP levels than their normal-weight counterparts (BMI,

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C2 - 10591334

SN - 0098-7484

VL - 282

SP - 2131

EP - 2135

JO - JAMA

JF - JAMA

IS - 0098-7484 (Print)

ER -

Elevated C-reactive protein levels in overweight and obese adults 1

Abstract

Keywords

UN SDGs

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