TY - JOUR
T1 - Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons
AU - Swart, C.M.A.
AU - van Schoor, N.M.
AU - Heijmans, M.W.
AU - Schaap, L.A.
AU - den Heijer, M.
AU - Lips, P.T.A.M.
PY - 2013
Y1 - 2013
N2 - Objective: The current study aimed to examine homocysteine in relation to different aspects of physical functioning. Design, setting and participants: Cross-sectional and longitudinal data (3-years follow-up) from the Longitudinal Aging Study Amsterdam (LASA) were used. The study was performed in persons aged ≥ 65 years (N= 1301 after imputation). Measurements: Different measures of physical functioning, including muscle mass, grip strength, functional limitations, and falling were regarded as outcomes. Gender and serum creatinine level were investigated as effect modifiers. Results: Results were stratified by gender. In men, higher homocysteine levels were associated with lower grip strength (Quartile 4: regression coefficient (B)= -3.07 (-4.91; -1.22)), and more functional limitations at baseline (Quartile 4: B= 1.15 (0.16-2.14)). In women, higher homocysteine levels were associated with more functional limitations after 3 years (Quartile 4: B= 1.19 (0.25; 2.13)). Higher homocysteine levels were not associated with low muscle mass or falling. Conclusions: These data suggest an inverse association of homocysteine levels with functional limitations in older men and women, and with muscle strength in older men. © 2013 Serdi and Springer-Verlag France.
AB - Objective: The current study aimed to examine homocysteine in relation to different aspects of physical functioning. Design, setting and participants: Cross-sectional and longitudinal data (3-years follow-up) from the Longitudinal Aging Study Amsterdam (LASA) were used. The study was performed in persons aged ≥ 65 years (N= 1301 after imputation). Measurements: Different measures of physical functioning, including muscle mass, grip strength, functional limitations, and falling were regarded as outcomes. Gender and serum creatinine level were investigated as effect modifiers. Results: Results were stratified by gender. In men, higher homocysteine levels were associated with lower grip strength (Quartile 4: regression coefficient (B)= -3.07 (-4.91; -1.22)), and more functional limitations at baseline (Quartile 4: B= 1.15 (0.16-2.14)). In women, higher homocysteine levels were associated with more functional limitations after 3 years (Quartile 4: B= 1.19 (0.25; 2.13)). Higher homocysteine levels were not associated with low muscle mass or falling. Conclusions: These data suggest an inverse association of homocysteine levels with functional limitations in older men and women, and with muscle strength in older men. © 2013 Serdi and Springer-Verlag France.
U2 - 10.1007/s12603-013-0047-2
DO - 10.1007/s12603-013-0047-2
M3 - Article
SN - 1279-7707
VL - 17
SP - 578
EP - 584
JO - Journal of Nutrition Health and Aging
JF - Journal of Nutrition Health and Aging
IS - 6
ER -