Elevated plasma inflammatory mediators in post-polio syndrome: No association with long-term functional decline

A. Bickerstaffe*, A. Beelen, R. Lutter, F. Nollet

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A key feature of post-polio syndrome (PPS) is progressive loss of muscle strength. In other chronic diseases systemic inflammation has been linked to muscle wasting. In this study plasma TNF-α, IL-6, IL-8, and leptin levels were significantly increased in PPS-patients compared to healthy controls. There was however no association between these raised systemic levels of inflammatory mediators and long-term decline in quadriceps strength or other clinical parameters. In conclusion, there is evidence for systemic inflammation in PPS, yet the relationship with clinical deterioration remains tenuous.

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalJournal of Neuroimmunology
Volume289
DOIs
Publication statusPublished - 15 Dec 2015
Externally publishedYes

Keywords

  • Cytokines
  • Motor neurons/pathology
  • Muscle strength
  • Postpoliomyelitis syndrome

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