Elimination kinetic model for organic chemicals in earthworms.

N. Dimitrova, S. Dimitrov, D. Georgieva, C.A.M. van Gestel, P. Hankard, D.J. Spurgeon, H. Li, O. Mekenyan

Research output: Contribution to JournalArticle

Abstract

Mechanistic understanding of bioaccumulation in different organisms and environments should take into account the influence of organism and chemical depending factors on the uptake and elimination kinetics of chemicals. Lipophilicity, metabolism, sorption (bioavailability) and biodegradation of chemicals are among the important factors that may significantly affect the bioaccumulation process in soil organisms. This study attempts to model elimination kinetics of organic chemicals in earthworms by accounting for the effects of both chemical and biological properties, including metabolism. The modeling approach that has been developed is based on the concept for simulating metabolism used in the BCF base-line model developed for predicting bioaccumulation in fish. Metabolism was explicitly accounted for by making use of the TIMES engine for simulation of metabolism and a set of principal transformations. Kinetic characteristics of transformations were estimated on the basis of observed kinetics data for the elimination of organic chemicals from earthworms. © 2010 Elsevier B.V.
Original languageEnglish
Pages (from-to)3787-3793
JournalScience of the Total Environment
Volume408
DOIs
Publication statusPublished - 2010

    Fingerprint

Cite this

Dimitrova, N., Dimitrov, S., Georgieva, D., van Gestel, C. A. M., Hankard, P., Spurgeon, D. J., ... Mekenyan, O. (2010). Elimination kinetic model for organic chemicals in earthworms. Science of the Total Environment, 408, 3787-3793. https://doi.org/10.1016/j.scitotenv.2010.01.064