Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

J.S. ten Kulve, D.J. Veltman, L. van Bloemendaal, F. Barkhof, C.F. Deacon, J.J. Holst, R.J. Konrad, J.H. Sloan, M.L. Drent, M. Diamant, R.G. IJzerman

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Aims/hypothesis: The central nervous system (CNS) is a major player in the regulation of food intake. The gut hormone glucagon-like peptide-1 (GLP-1) has been proposed to have an important role in this regulation by relaying information about nutritional status to the CNS. We hypothesised that endogenous GLP-1 has effects on CNS reward and satiety circuits. Methods: This was a randomised, crossover, placebo-controlled intervention study, performed in a university medical centre in the Netherlands. We included patients with type 2 diabetes and healthy lean control subjects. Individuals were eligible if they were 40–65 years. Inclusion criteria for the healthy lean individuals included a BMI <25 kg/m
    Original languageEnglish
    Pages (from-to)2688-2698
    JournalDiabetologia
    Volume58
    Issue number12
    DOIs
    Publication statusPublished - 2015

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