Endoscopic polarization-sensitive optical coherence tomography in multiple lung diseases (Conference Presentation)

Joy Willemse; Reinier Wener; Fabio Feroldi; Margherita Vaselli; Maximilian G. O. Graefe; Johannes F. de Boer

doi:10.1117/12.2548916

Endoscopic polarization-sensitive optical coherence tomography in multiple lung diseases (Conference Presentation)

Joy Willemse, Reinier Wener, Fabio Feroldi, Margherita Vaselli, Maximilian G. O. Graefe, Johannes F. de Boer

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Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) has been used to extract polarization properties of four different diseased lungs ex vivo, including fibrotic sarcoidosis (FS), chronic obstructive pulmonary disease (COPD), fibrotic extrinsic allergic alveolitis (fibrotic EAA) and cystic fibrosis (CF). An increase in alveoli size has been observed in COPD lungs. Furthermore, an increase in birefringence signal was observed for FS and fibrotic EAA. In CF, a few areas with thick patches of birefringence occurred. The results show potential of in vivo assessment of lung fibrosis. Histology slides of all lungs were acquired, and will be used to further interpret the results.

Original language	English
DOIs	https://doi.org/10.1117/12.2548916
Publication status	Published - 9 Mar 2020
Event	SPIE BiOS 2020 - Online, San Francisco, United States Duration: 1 Feb 2020 → 6 Feb 2020

Conference

Conference	SPIE BiOS 2020
Country/Territory	United States
City	San Francisco
Period	1/02/20 → 6/02/20

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title = "Endoscopic polarization-sensitive optical coherence tomography in multiple lung diseases (Conference Presentation)",

abstract = "Polarization-sensitive optical coherence tomography (PS-OCT) has been used to extract polarization properties of four different diseased lungs ex vivo, including fibrotic sarcoidosis (FS), chronic obstructive pulmonary disease (COPD), fibrotic extrinsic allergic alveolitis (fibrotic EAA) and cystic fibrosis (CF). An increase in alveoli size has been observed in COPD lungs. Furthermore, an increase in birefringence signal was observed for FS and fibrotic EAA. In CF, a few areas with thick patches of birefringence occurred. The results show potential of in vivo assessment of lung fibrosis. Histology slides of all lungs were acquired, and will be used to further interpret the results.",

author = "Joy Willemse and Reinier Wener and Fabio Feroldi and Margherita Vaselli and Graefe, {Maximilian G. O.} and {de Boer}, {Johannes F.}",

year = "2020",

month = mar,

day = "9",

doi = "10.1117/12.2548916",

language = "English",

note = "SPIE BiOS 2020 ; Conference date: 01-02-2020 Through 06-02-2020",

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TY - CONF

T1 - Endoscopic polarization-sensitive optical coherence tomography in multiple lung diseases (Conference Presentation)

AU - Willemse, Joy

AU - Wener, Reinier

AU - Feroldi, Fabio

AU - Vaselli, Margherita

AU - Graefe, Maximilian G. O.

AU - de Boer, Johannes F.

PY - 2020/3/9

Y1 - 2020/3/9

N2 - Polarization-sensitive optical coherence tomography (PS-OCT) has been used to extract polarization properties of four different diseased lungs ex vivo, including fibrotic sarcoidosis (FS), chronic obstructive pulmonary disease (COPD), fibrotic extrinsic allergic alveolitis (fibrotic EAA) and cystic fibrosis (CF). An increase in alveoli size has been observed in COPD lungs. Furthermore, an increase in birefringence signal was observed for FS and fibrotic EAA. In CF, a few areas with thick patches of birefringence occurred. The results show potential of in vivo assessment of lung fibrosis. Histology slides of all lungs were acquired, and will be used to further interpret the results.

AB - Polarization-sensitive optical coherence tomography (PS-OCT) has been used to extract polarization properties of four different diseased lungs ex vivo, including fibrotic sarcoidosis (FS), chronic obstructive pulmonary disease (COPD), fibrotic extrinsic allergic alveolitis (fibrotic EAA) and cystic fibrosis (CF). An increase in alveoli size has been observed in COPD lungs. Furthermore, an increase in birefringence signal was observed for FS and fibrotic EAA. In CF, a few areas with thick patches of birefringence occurred. The results show potential of in vivo assessment of lung fibrosis. Histology slides of all lungs were acquired, and will be used to further interpret the results.

UR - https://www.mendeley.com/catalogue/5398a403-2797-3cf7-9315-02c91c189785/

U2 - 10.1117/12.2548916

DO - 10.1117/12.2548916

M3 - Paper

T2 - SPIE BiOS 2020

Y2 - 1 February 2020 through 6 February 2020

ER -

Endoscopic polarization-sensitive optical coherence tomography in multiple lung diseases (Conference Presentation)

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