Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes.

A.M. Spijkerman; M.A. Gall; L. Tarnow; J.W.R. Twisk; E. Lauritzen; H. Lund-Andersen; J. Emeis; H.H. Parving; C.D.A. Stehouwer

doi:10.1111/j.1464-5491.2007.02217.x

Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes.

A.M. Spijkerman, M.A. Gall, L. Tarnow, J.W.R. Twisk, E. Lauritzen, H. Lund-Andersen, J. Emeis, H.H. Parving, C.D.A. Stehouwer

Methodology and Applied Biostatistics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after pupillary dilatation by direct ophthalmoscopy (baseline) and two-field 60°fundus photography (follow-up). Urinary albumin excretion, and markers of endothelial function (von Willebrand factor, tissue-type plasminogen activator, soluble E-selectin (sE-selectin), and soluble vascular cell adhesion molecule 1) and inflammatory activity (C-reactive protein and fibrinogen) were determined. Results: The prevalence of retinopathy was 33.8%. The median diabetes duration at baseline was 7 years (interquartile range 2-12 years). The highest tertiles of baseline urinary albumin excretion and glycated haemoglobin (HbA

Original language	English
Pages (from-to)	969-976
Journal	Diabetic Medicine
Volume	24
DOIs	https://doi.org/10.1111/j.1464-5491.2007.02217.x
Publication status	Published - 2007

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Sep 2007

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10.1111/j.1464-5491.2007.02217.x

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title = "Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes.",

abstract = "Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after pupillary dilatation by direct ophthalmoscopy (baseline) and two-field 60°fundus photography (follow-up). Urinary albumin excretion, and markers of endothelial function (von Willebrand factor, tissue-type plasminogen activator, soluble E-selectin (sE-selectin), and soluble vascular cell adhesion molecule 1) and inflammatory activity (C-reactive protein and fibrinogen) were determined. Results: The prevalence of retinopathy was 33.8%. The median diabetes duration at baseline was 7 years (interquartile range 2-12 years). The highest tertiles of baseline urinary albumin excretion and glycated haemoglobin (HbA",

author = "A.M. Spijkerman and M.A. Gall and L. Tarnow and J.W.R. Twisk and E. Lauritzen and H. Lund-Andersen and J. Emeis and H.H. Parving and C.D.A. Stehouwer",

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T1 - Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes.

AU - Spijkerman, A.M.

AU - Gall, M.A.

AU - Tarnow, L.

AU - Twisk, J.W.R.

AU - Lauritzen, E.

AU - Lund-Andersen, H.

AU - Emeis, J.

AU - Parving, H.H.

AU - Stehouwer, C.D.A.

N1 - Sep 2007

PY - 2007

Y1 - 2007

N2 - Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after pupillary dilatation by direct ophthalmoscopy (baseline) and two-field 60°fundus photography (follow-up). Urinary albumin excretion, and markers of endothelial function (von Willebrand factor, tissue-type plasminogen activator, soluble E-selectin (sE-selectin), and soluble vascular cell adhesion molecule 1) and inflammatory activity (C-reactive protein and fibrinogen) were determined. Results: The prevalence of retinopathy was 33.8%. The median diabetes duration at baseline was 7 years (interquartile range 2-12 years). The highest tertiles of baseline urinary albumin excretion and glycated haemoglobin (HbA

AB - Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after pupillary dilatation by direct ophthalmoscopy (baseline) and two-field 60°fundus photography (follow-up). Urinary albumin excretion, and markers of endothelial function (von Willebrand factor, tissue-type plasminogen activator, soluble E-selectin (sE-selectin), and soluble vascular cell adhesion molecule 1) and inflammatory activity (C-reactive protein and fibrinogen) were determined. Results: The prevalence of retinopathy was 33.8%. The median diabetes duration at baseline was 7 years (interquartile range 2-12 years). The highest tertiles of baseline urinary albumin excretion and glycated haemoglobin (HbA

U2 - 10.1111/j.1464-5491.2007.02217.x

DO - 10.1111/j.1464-5491.2007.02217.x

M3 - Article

SN - 0742-3071

VL - 24

SP - 969

EP - 976

JO - Diabetic Medicine

JF - Diabetic Medicine

ER -

Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes.

Abstract

Bibliographical note

UN SDGs

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