Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes.

A.M. Spijkerman, M.A. Gall, L. Tarnow, J.W.R. Twisk, E. Lauritzen, H. Lund-Andersen, J. Emeis, H.H. Parving, C.D.A. Stehouwer

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Aims: To study whether microalbuminuria, endothelial dysfunction and low-grade inflammation are associated with the presence and progression of diabetic retinopathy. Methods: Patients with Type 2 diabetes (n = 328) attending a diabetes clinic were followed for 10 years and examined annually during the last 7 years. Retinopathy was assessed after pupillary dilatation by direct ophthalmoscopy (baseline) and two-field 60°fundus photography (follow-up). Urinary albumin excretion, and markers of endothelial function (von Willebrand factor, tissue-type plasminogen activator, soluble E-selectin (sE-selectin), and soluble vascular cell adhesion molecule 1) and inflammatory activity (C-reactive protein and fibrinogen) were determined. Results: The prevalence of retinopathy was 33.8%. The median diabetes duration at baseline was 7 years (interquartile range 2-12 years). The highest tertiles of baseline urinary albumin excretion and glycated haemoglobin (HbA
Original languageEnglish
Pages (from-to)969-976
JournalDiabetic Medicine
Volume24
DOIs
Publication statusPublished - 2007

Bibliographical note

Sep 2007

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