ENIGMA-Sleep: Challenges, opportunities, and the road map

Masoud Tahmasian; André Aleman; Ole A. Andreassen; Zahra Arab; Marion Baillet; Francesco Benedetti; Tom Bresser; Joanna Bright; Michael W.L. Chee; Daphne Chylinski; Wei Cheng; Michele Deantoni; Martin Dresler; Simon B. Eickhoff; Claudia R. Eickhoff; Torbjørn Elvsåshagen; Jianfeng Feng; Jessica C. Foster-Dingley; Habib Ganjgahi; Hans J. Grabe; Nynke A. Groenewold; Tiffany C. Ho; Seung Bong Hong; Josselin Houenou; Benson Irungu; Neda Jahanshad; Habibolah Khazaie; Hosung Kim; Ekaterina Koshmanova; Desi Kocevska; Peter Kochunov; Oti Lakbila-Kamal; Jeanne Leerssen; Meng Li; Annemarie I. Luik; Vincenzo Muto; Justinas Narbutas; Gustav Nilsonne; Victoria S. O’Callaghan; Alexander Olsen; Ricardo S. Osorio; Sara Poletti; Govinda Poudel; Joyce E. Reesen; Liesbeth Reneman; Mathilde Reyt; Dieter Riemann; Ivana Rosenzweig; Masoumeh Rostampour; Amin Saberi; Julian Schiel; Christina Schmidt; Anouk Schrantee; Emma Sciberras; Tim J. Silk; Kang Sim; Hanne Smevik; Jair C. Soares; Kai Spiegelhalder; Dan J. Stein; Puneet Talwar; Sandra Tamm; Giana l. Teresi; Sofie L. Valk; Eus Van Someren; Gilles Vandewalle; Maxime Van Egroo; Henry Völzke; Martin Walter; Rick Wassing; Frederik D. Weber; Antoine Weihs; Lars Tjelta Westlye; Margaret J. Wright; Mon Ju Wu; Nathalia Zak; Mojtaba Zarei

doi:10.1111/jsr.13347

ENIGMA-Sleep: Challenges, opportunities, and the road map

Masoud Tahmasian^*, André Aleman, Ole A. Andreassen, Zahra Arab, Marion Baillet, Francesco Benedetti, Tom Bresser, Joanna Bright, Michael W.L. Chee, Daphne Chylinski, Wei Cheng, Michele Deantoni, Martin Dresler, Simon B. Eickhoff, Claudia R. Eickhoff, Torbjørn Elvsåshagen, Jianfeng Feng, Jessica C. Foster-Dingley, Habib Ganjgahi, Hans J. GrabeNynke A. Groenewold, Tiffany C. Ho, Seung Bong Hong, Josselin Houenou, Benson Irungu, Neda Jahanshad, Habibolah Khazaie, Hosung Kim, Ekaterina Koshmanova, Desi Kocevska, Peter Kochunov, Oti Lakbila-Kamal, Jeanne Leerssen, Meng Li, Annemarie I. Luik, Vincenzo Muto, Justinas Narbutas, Gustav Nilsonne, Victoria S. O’Callaghan, Alexander Olsen, Ricardo S. Osorio, Sara Poletti, Govinda Poudel, Joyce E. Reesen, Liesbeth Reneman, Mathilde Reyt, Dieter Riemann, Ivana Rosenzweig, Masoumeh Rostampour, Amin Saberi, Julian Schiel, Christina Schmidt, Anouk Schrantee, Emma Sciberras, Tim J. Silk, Kang Sim, Hanne Smevik, Jair C. Soares, Kai Spiegelhalder, Dan J. Stein, Puneet Talwar, Sandra Tamm, Giana l. Teresi, Sofie L. Valk, Eus Van Someren, Gilles Vandewalle, Maxime Van Egroo, Henry Völzke, Martin Walter, Rick Wassing, Frederik D. Weber, Antoine Weihs, Lars Tjelta Westlye, Margaret J. Wright, Mon Ju Wu, Nathalia Zak, Mojtaba Zarei

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

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Abstract

Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine.

Original language	English
Article number	e13347
Pages (from-to)	1-20
Number of pages	20
Journal	Journal of Sleep Research
Volume	30
Issue number	6
Early online date	28 Apr 2021
DOIs	https://doi.org/10.1111/jsr.13347
Publication status	Published - Dec 2021

Bibliographical note

Funding Information:
GN was supported by Riksbankens Jubileumsfond (grant no. P15‐0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS‐FNRS Belgium). The research included here was funded by Wallonia‐Brussels Federation (ARC ‐ 09/14‐03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO‐CR‐2010‐06E), FNRS‐Belgium (FRS‐FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Liège (ULiège), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC‐Starting Grant ‐ GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13‐1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg‐West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg‐West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care.

Funding Information:
GN was supported by Riksbankens Jubileumsfond (grant no. P15-0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS-FNRS Belgium). The research included here was funded by Wallonia-Brussels Federation (ARC - 09/14-03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO-CR-2010-06E), FNRS-Belgium (FRS-FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Li?ge (ULi?ge), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC-Starting Grant - GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13-1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg-West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care.

Publisher Copyright:
© 2021 European Sleep Research Society

Funding

GN was supported by Riksbankens Jubileumsfond (grant no. P15‐0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS‐FNRS Belgium). The research included here was funded by Wallonia‐Brussels Federation (ARC ‐ 09/14‐03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO‐CR‐2010‐06E), FNRS‐Belgium (FRS‐FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Liège (ULiège), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC‐Starting Grant ‐ GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13‐1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg‐West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg‐West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. GN was supported by Riksbankens Jubileumsfond (grant no. P15-0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS-FNRS Belgium). The research included here was funded by Wallonia-Brussels Federation (ARC - 09/14-03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO-CR-2010-06E), FNRS-Belgium (FRS-FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Li?ge (ULi?ge), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC-Starting Grant - GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13-1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg-West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care.

Funders	Funder number
Dagmar Dolby Family Fund
FNRS-Belgium
FNRS‐Belgium	3.4516.11
Federal State of Mecklenburg-West Pomerania
Federal State of Mecklenburg‐West Pomerania
Fondation Simone et Pierre Clerdent
German Federal State of Mecklenburg-West Pomerania
German Federal State of Mecklenburg‐West Pomerania
German Restless Legs Syndrome Society
National Funds FNRS
Research Institute for Diseases in the Elderly
Wallonia-Brussels Federation	ARC - 09/14-03
Wallonia‐Brussels Federation
National Institute of Mental Health	K01MH117442
National Institute on Aging	R01AG056531
Respiratory Health Association
Norges Teknisk-Naturvitenskapelige Universitet
Fresenius Medical Care North America
European Commission
European Research Council	GA 757763
Australian Research Council	09/14‐03
Deutsche Forschungsgemeinschaft	GR 1912/13‐1
ZonMw
Erasmus Universiteit Rotterdam
Ministerie van Volksgezondheid, Welzijn en Sport
Erasmus Medisch Centrum
Ministerie van Onderwijs, Cultuur en Wetenschap
Max-Planck-Gesellschaft
Riksbankens Jubileumsfond	P15‐0310:1
Helse Midt-Norge
Université de Liège
European Regional Development Fund
Walloon Excellence in Life Sciences and Biotechnology	WELBIO‐CR‐2010‐06E

Keywords

ENIGMA consortium
large-scale collaboration
neurogenetics
neuroimaging
sleep

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jsr.13347

ENIGMA-Sleep_Challenges, opportunities, and the road mapFinal published version, 1.28 MBLicence: Article 25fa Dutch Copyright Act

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Cite this

Tahmasian, M., Aleman, A., Andreassen, O. A., Arab, Z., Baillet, M., Benedetti, F., Bresser, T., Bright, J., Chee, M. W. L., Chylinski, D., Cheng, W., Deantoni, M., Dresler, M., Eickhoff, S. B., Eickhoff, C. R., Elvsåshagen, T., Feng, J., Foster-Dingley, J. C., Ganjgahi, H., ... Zarei, M. (2021). ENIGMA-Sleep: Challenges, opportunities, and the road map. Journal of Sleep Research, 30(6), 1-20. Article e13347. https://doi.org/10.1111/jsr.13347

@article{003f33a1756a47d2903eb2951ffe845f,

title = "ENIGMA-Sleep: Challenges, opportunities, and the road map",

abstract = "Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine.",

keywords = "ENIGMA consortium, large-scale collaboration, neurogenetics, neuroimaging, sleep",

author = "Masoud Tahmasian and Andr{\'e} Aleman and Andreassen, {Ole A.} and Zahra Arab and Marion Baillet and Francesco Benedetti and Tom Bresser and Joanna Bright and Chee, {Michael W.L.} and Daphne Chylinski and Wei Cheng and Michele Deantoni and Martin Dresler and Eickhoff, {Simon B.} and Eickhoff, {Claudia R.} and Torbj{\o}rn Elvs{\aa}shagen and Jianfeng Feng and Foster-Dingley, {Jessica C.} and Habib Ganjgahi and Grabe, {Hans J.} and Groenewold, {Nynke A.} and Ho, {Tiffany C.} and {Bong Hong}, Seung and Josselin Houenou and Benson Irungu and Neda Jahanshad and Habibolah Khazaie and Hosung Kim and Ekaterina Koshmanova and Desi Kocevska and Peter Kochunov and Oti Lakbila-Kamal and Jeanne Leerssen and Meng Li and Luik, {Annemarie I.} and Vincenzo Muto and Justinas Narbutas and Gustav Nilsonne and O{\textquoteright}Callaghan, {Victoria S.} and Alexander Olsen and Osorio, {Ricardo S.} and Sara Poletti and Govinda Poudel and Reesen, {Joyce E.} and Liesbeth Reneman and Mathilde Reyt and Dieter Riemann and Ivana Rosenzweig and Masoumeh Rostampour and Amin Saberi and Julian Schiel and Christina Schmidt and Anouk Schrantee and Emma Sciberras and Silk, {Tim J.} and Kang Sim and Hanne Smevik and Soares, {Jair C.} and Kai Spiegelhalder and Stein, {Dan J.} and Puneet Talwar and Sandra Tamm and Teresi, {Giana l.} and Valk, {Sofie L.} and {Van Someren}, Eus and Gilles Vandewalle and {Van Egroo}, Maxime and Henry V{\"o}lzke and Martin Walter and Rick Wassing and Weber, {Frederik D.} and Antoine Weihs and Westlye, {Lars Tjelta} and Wright, {Margaret J.} and Wu, {Mon Ju} and Nathalia Zak and Mojtaba Zarei",

note = "Funding Information: GN was supported by Riksbankens Jubileumsfond (grant no. P15‐0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS‐FNRS Belgium). The research included here was funded by Wallonia‐Brussels Federation (ARC ‐ 09/14‐03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO‐CR‐2010‐06E), FNRS‐Belgium (FRS‐FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Li{\`e}ge (ULi{\`e}ge), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC‐Starting Grant ‐ GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13‐1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg‐West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg‐West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. Funding Information: GN was supported by Riksbankens Jubileumsfond (grant no. P15-0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS-FNRS Belgium). The research included here was funded by Wallonia-Brussels Federation (ARC - 09/14-03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO-CR-2010-06E), FNRS-Belgium (FRS-FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Li?ge (ULi?ge), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC-Starting Grant - GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13-1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg-West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. Publisher Copyright: {\textcopyright} 2021 European Sleep Research Society",

year = "2021",

month = dec,

doi = "10.1111/jsr.13347",

language = "English",

volume = "30",

pages = "1--20",

journal = "Journal of Sleep Research",

issn = "0962-1105",

publisher = "John Wiley and Sons Inc.",

number = "6",

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Tahmasian, M, Aleman, A, Andreassen, OA, Arab, Z, Baillet, M, Benedetti, F, Bresser, T, Bright, J, Chee, MWL, Chylinski, D, Cheng, W, Deantoni, M, Dresler, M, Eickhoff, SB, Eickhoff, CR, Elvsåshagen, T, Feng, J, Foster-Dingley, JC, Ganjgahi, H, Grabe, HJ, Groenewold, NA, Ho, TC, Bong Hong, S, Houenou, J, Irungu, B, Jahanshad, N, Khazaie, H, Kim, H, Koshmanova, E, Kocevska, D, Kochunov, P, Lakbila-Kamal, O, Leerssen, J, Li, M, Luik, AI, Muto, V, Narbutas, J, Nilsonne, G, O’Callaghan, VS, Olsen, A, Osorio, RS, Poletti, S, Poudel, G, Reesen, JE, Reneman, L, Reyt, M, Riemann, D, Rosenzweig, I, Rostampour, M, Saberi, A, Schiel, J, Schmidt, C, Schrantee, A, Sciberras, E, Silk, TJ, Sim, K, Smevik, H, Soares, JC, Spiegelhalder, K, Stein, DJ, Talwar, P, Tamm, S, Teresi, GL, Valk, SL, Van Someren, E, Vandewalle, G, Van Egroo, M, Völzke, H, Walter, M, Wassing, R, Weber, FD, Weihs, A, Westlye, LT, Wright, MJ, Wu, MJ, Zak, N & Zarei, M 2021, 'ENIGMA-Sleep: Challenges, opportunities, and the road map', Journal of Sleep Research, vol. 30, no. 6, e13347, pp. 1-20. https://doi.org/10.1111/jsr.13347

TY - JOUR

T1 - ENIGMA-Sleep: Challenges, opportunities, and the road map

AU - Tahmasian, Masoud

AU - Aleman, André

AU - Andreassen, Ole A.

AU - Arab, Zahra

AU - Baillet, Marion

AU - Benedetti, Francesco

AU - Bresser, Tom

AU - Bright, Joanna

AU - Chee, Michael W.L.

AU - Chylinski, Daphne

AU - Cheng, Wei

AU - Deantoni, Michele

AU - Dresler, Martin

AU - Eickhoff, Simon B.

AU - Eickhoff, Claudia R.

AU - Elvsåshagen, Torbjørn

AU - Feng, Jianfeng

AU - Foster-Dingley, Jessica C.

AU - Ganjgahi, Habib

AU - Grabe, Hans J.

AU - Groenewold, Nynke A.

AU - Ho, Tiffany C.

AU - Bong Hong, Seung

AU - Houenou, Josselin

AU - Irungu, Benson

AU - Jahanshad, Neda

AU - Khazaie, Habibolah

AU - Kim, Hosung

AU - Koshmanova, Ekaterina

AU - Kocevska, Desi

AU - Kochunov, Peter

AU - Lakbila-Kamal, Oti

AU - Leerssen, Jeanne

AU - Li, Meng

AU - Luik, Annemarie I.

AU - Muto, Vincenzo

AU - Narbutas, Justinas

AU - Nilsonne, Gustav

AU - O’Callaghan, Victoria S.

AU - Olsen, Alexander

AU - Osorio, Ricardo S.

AU - Poletti, Sara

AU - Poudel, Govinda

AU - Reesen, Joyce E.

AU - Reneman, Liesbeth

AU - Reyt, Mathilde

AU - Riemann, Dieter

AU - Rosenzweig, Ivana

AU - Rostampour, Masoumeh

AU - Saberi, Amin

AU - Schiel, Julian

AU - Schmidt, Christina

AU - Schrantee, Anouk

AU - Sciberras, Emma

AU - Silk, Tim J.

AU - Sim, Kang

AU - Smevik, Hanne

AU - Soares, Jair C.

AU - Spiegelhalder, Kai

AU - Stein, Dan J.

AU - Talwar, Puneet

AU - Tamm, Sandra

AU - Teresi, Giana l.

AU - Valk, Sofie L.

AU - Van Someren, Eus

AU - Vandewalle, Gilles

AU - Van Egroo, Maxime

AU - Völzke, Henry

AU - Walter, Martin

AU - Wassing, Rick

AU - Weber, Frederik D.

AU - Weihs, Antoine

AU - Westlye, Lars Tjelta

AU - Wright, Margaret J.

AU - Wu, Mon Ju

AU - Zak, Nathalia

AU - Zarei, Mojtaba

N1 - Funding Information: GN was supported by Riksbankens Jubileumsfond (grant no. P15‐0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS‐FNRS Belgium). The research included here was funded by Wallonia‐Brussels Federation (ARC ‐ 09/14‐03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO‐CR‐2010‐06E), FNRS‐Belgium (FRS‐FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Liège (ULiège), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC‐Starting Grant ‐ GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13‐1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg‐West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg‐West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. Funding Information: GN was supported by Riksbankens Jubileumsfond (grant no. P15-0310:1). SLV was supported by the Otto Hahn award of the Max Planck Society. AO was supported by the Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU). GV and CS are funded by National Funds FNRS Scientific Research (FRS-FNRS Belgium). The research included here was funded by Wallonia-Brussels Federation (ARC - 09/14-03), WELBIO/Walloon Excellence in Life Sciences and Biotechnology Grant (WELBIO-CR-2010-06E), FNRS-Belgium (FRS-FNRS, F.4513.17 & T.0242.19 & 3.4516.11), University of Li?ge (ULi?ge), Fondation Simone et Pierre Clerdent, European Regional Development Fund (Radiomed project), European Research Council (ERC-Starting Grant - GA 757763). The Rotterdam Study is funded by Erasmus Medical Center and Erasmus University, Rotterdam, Netherlands Organization for the Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission (DG XII), and the Municipality of Rotterdam. TCH is supported by the National Institute of Mental Health (K01MH117442) and the Ray and Dagmar Dolby Family Fund. AW was supported by the Deutsche Forschungsgemeinschaft (DFG, grant number: GR 1912/13-1). The Study of Health in Pomerania (SHIP) is supported by the German Federal State of Mecklenburg-West Pomerania. MRI scans have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania, and PSG assessment was in part supported by the Deutsche RLS e.V. (German Restless Legs Syndrome Society). HJG has received travel grants and speakers honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. Publisher Copyright: © 2021 European Sleep Research Society

PY - 2021/12

Y1 - 2021/12

N2 - Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine.

AB - Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine.

KW - ENIGMA consortium

KW - large-scale collaboration

KW - neurogenetics

KW - neuroimaging

KW - sleep

UR - http://www.scopus.com/inward/record.url?scp=85105413413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85105413413&partnerID=8YFLogxK

U2 - 10.1111/jsr.13347

DO - 10.1111/jsr.13347

M3 - Review article

C2 - 33913199

SN - 0962-1105

VL - 30

SP - 1

EP - 20

JO - Journal of Sleep Research

JF - Journal of Sleep Research

IS - 6

M1 - e13347

ER -

ENIGMA-Sleep: Challenges, opportunities, and the road map

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