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Epigenetics, Changing Organizational Contexts, Personality Traits, Stress Regulation and Burnout: An Integrative Multi-Adaptive Biological-Mental-Social Network Analysis

  • Debby Bouma
  • , Jan Treur*
  • , Sophie C.F. Hendrikse
  • *Corresponding author for this work

Research output: Chapter in Book / Report / Conference proceedingChapterAcademicpeer-review

Abstract

This research addresses the interplay of changing social and organizational context factors with the big five personality traits and the three main characterizing elements of a burnout. A computational analysis is contributed based on an integrative biological-mental-social network modeling approach. The simulation results show how two people who are high in personality traits such as agreeableness, openness, extraversion, conscientiousness, and highly sensitive for neuroticism, are vulnerable to reach a burnout level in all dimensions whenever the organizational context is changing in a less favorable direction. By a What-If analysis it is analysed how important characteristics affect the outcomes and indicate how in a qualitative sense that is in line with empirical literature. Several differentiations are made. In particular, the connection between the three dimensions of a burnout shows that it is possible that one employee reaches a burnout state while the other does not. It is also shown how therapy alone may not be sufficient as a long-term treatment, but therapy of one employee does affect the other. As numerical data are not (yet) available, further numerical validation has been proposed for future work.

Original languageEnglish
Title of host publicationStudies in Systems, Decision and Control
PublisherSpringer Science and Business Media Deutschland GmbH
Pages181-221
Number of pages41
DOIs
Publication statusPublished - 2026

Publication series

NameStudies in Systems, Decision and Control
Volume662
ISSN (Print)2198-4182
ISSN (Electronic)2198-4190

Bibliographical note

Publisher Copyright:
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2026.

Keywords

  • Burnout
  • Integrative
  • Job demands
  • Multi-adaptive network model
  • Personality traits
  • Social and organisational context

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