Epigenome-Wide Association Study of Tic Disorders

N. Rodrigues Zilhao Nogueira; S.S. Padmanabhuni; L. Pagliaroli; C. Barta; D.J.A. Smit; D.C. Cath; M.G. Nivard; B.M.L. Baselmans; J. van Dongen; P. Paschou; D.I. Boomsma

doi:10.1017/thg.2015.72

Epigenome-Wide Association Study of Tic Disorders

N. Rodrigues Zilhao Nogueira, S.S. Padmanabhuni, L. Pagliaroli, C. Barta, D.J.A. Smit, D.C. Cath, M.G. Nivard, B.M.L. Baselmans, J. van Dongen, P. Paschou, D.I. Boomsma

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p < 1.2 × 10

Original language	English
Pages (from-to)	699-709
Number of pages	11
Journal	Twin Research and Human Genetics
Volume	18
Issue number	6
DOIs	https://doi.org/10.1017/thg.2015.72
Publication status	Published - 2015

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1017/thg.2015.72

Persistent URL (handle)

Persistent link

Cite this

@article{fd395f2fbbbf49c38e31692ac587df96,

title = "Epigenome-Wide Association Study of Tic Disorders",

abstract = "Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p < 1.2 × 10",

author = "{Rodrigues Zilhao Nogueira}, N. and S.S. Padmanabhuni and L. Pagliaroli and C. Barta and D.J.A. Smit and D.C. Cath and M.G. Nivard and B.M.L. Baselmans and {van Dongen}, J. and P. Paschou and D.I. Boomsma",

year = "2015",

doi = "10.1017/thg.2015.72",

language = "English",

volume = "18",

pages = "699--709",

journal = "Twin Research and Human Genetics",

issn = "1832-4274",

publisher = "Cambridge University Press",

number = "6",

}

TY - JOUR

T1 - Epigenome-Wide Association Study of Tic Disorders

AU - Rodrigues Zilhao Nogueira, N.

AU - Padmanabhuni, S.S.

AU - Pagliaroli, L.

AU - Barta, C.

AU - Smit, D.J.A.

AU - Cath, D.C.

AU - Nivard, M.G.

AU - Baselmans, B.M.L.

AU - van Dongen, J.

AU - Paschou, P.

AU - Boomsma, D.I.

PY - 2015

Y1 - 2015

N2 - Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p < 1.2 × 10

AB - Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p < 1.2 × 10

U2 - 10.1017/thg.2015.72

DO - 10.1017/thg.2015.72

M3 - Article

SN - 1832-4274

VL - 18

SP - 699

EP - 709

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

IS - 6

ER -

Epigenome-Wide Association Study of Tic Disorders

Abstract

Cohort Studies

Access to Document

Persistent URL (handle)

Fingerprint

Cite this