Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study

Vera A van Atteveld, Jeanine M Van Ancum, Esmee M Reijnierse, Marijke C Trappenburg, Carel G M Meskers, Andrea B Maier

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

BACKGROUND: Chronic inflammation is considered to affect physical performance, muscle strength and muscle mass, i.e. measures of sarcopenia. We need to identify a marker of inflammation that is univocally associated with measures of sarcopenia. We aimed to associate three markers of inflammation, erythrocyte sedimentation rate, albumin and white blood cell count, with measures of sarcopenia in geriatric outpatients.

METHODS: Data from the Centre Of Geriatrics Amsterdam cohort was used. Geriatric outpatients at the VU university medical centre in Amsterdam were recruited based on referral between January 1st 2014 and the 31st of December 2015. Erythrocyte sedimentation rate, albumin and white blood cell count were assessed from venous blood samples. Measures of sarcopenia included physical performance by measuring gait speed with the 4 meter walk test, duration of the timed up and go test and of the chair stand test, muscle strength by assessing handgrip strength using handheld dynamometry and skeletal muscle mass by performing bioelectrical impedance analysis. Multivariable linear regression analyses were performed to assess the associations between erythrocyte sedimentation rate, albumin, white blood cell count and measures of sarcopenia.

RESULTS: A total of 442 patients (mean age 80.8 years, SD 6.7, 58.1% female) were included. A higher erythrocyte sedimentation rate was significantly associated with lower gait speed (β = - 0.005; 95% CI = - 0.007, - 0.003), longer duration of timed up and go test (Ln β = 0.006; 95% CI = 0.003, 0.010), longer duration of chair stand test (Ln β = 0.005; 95% CI = 0.002, 0.008), lower handgrip strength (β = - 0.126; 95% CI = - 0.189, - 0.063) and lower relative skeletal muscle mass (β = - 0.179; 95% CI = - 0.274, - 0.084). Lower albumin levels were significantly associated with lower gait speed (β = - 0.020; 95% CI = - 0.011, - 0.028) and handgrip strength (β = - 0.596; 95% CI = - 0.311, - 0.881). Associations remained significant after adjustment for age, sex and number of morbidities. No significant associations were found for white blood cell count and measures of sarcopenia.

CONCLUSIONS: In geriatric outpatients, erythrocyte sedimentation rate was associated with all three measures of sarcopenia, underpinning the potential role of inflammation in sarcopenia.

Original languageEnglish
Article number233
Pages (from-to)233
JournalBMC Geriatrics
Volume19
Issue number1
DOIs
Publication statusPublished - 27 Aug 2019

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Sarcopenia
Blood Sedimentation
Albumins
Cross-Sectional Studies
Inflammation
Leukocyte Count
Geriatrics
Outpatients
Muscle Strength
Skeletal Muscle
Electric Impedance
Linear Models
Referral and Consultation
Regression Analysis
Morbidity
Muscles

Cite this

van Atteveld, Vera A ; Van Ancum, Jeanine M ; Reijnierse, Esmee M ; Trappenburg, Marijke C ; Meskers, Carel G M ; Maier, Andrea B. / Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia : a cross-sectional study. In: BMC Geriatrics. 2019 ; Vol. 19, No. 1. pp. 233.
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title = "Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia: a cross-sectional study",
abstract = "BACKGROUND: Chronic inflammation is considered to affect physical performance, muscle strength and muscle mass, i.e. measures of sarcopenia. We need to identify a marker of inflammation that is univocally associated with measures of sarcopenia. We aimed to associate three markers of inflammation, erythrocyte sedimentation rate, albumin and white blood cell count, with measures of sarcopenia in geriatric outpatients.METHODS: Data from the Centre Of Geriatrics Amsterdam cohort was used. Geriatric outpatients at the VU university medical centre in Amsterdam were recruited based on referral between January 1st 2014 and the 31st of December 2015. Erythrocyte sedimentation rate, albumin and white blood cell count were assessed from venous blood samples. Measures of sarcopenia included physical performance by measuring gait speed with the 4 meter walk test, duration of the timed up and go test and of the chair stand test, muscle strength by assessing handgrip strength using handheld dynamometry and skeletal muscle mass by performing bioelectrical impedance analysis. Multivariable linear regression analyses were performed to assess the associations between erythrocyte sedimentation rate, albumin, white blood cell count and measures of sarcopenia.RESULTS: A total of 442 patients (mean age 80.8 years, SD 6.7, 58.1{\%} female) were included. A higher erythrocyte sedimentation rate was significantly associated with lower gait speed (β = - 0.005; 95{\%} CI = - 0.007, - 0.003), longer duration of timed up and go test (Ln β = 0.006; 95{\%} CI = 0.003, 0.010), longer duration of chair stand test (Ln β = 0.005; 95{\%} CI = 0.002, 0.008), lower handgrip strength (β = - 0.126; 95{\%} CI = - 0.189, - 0.063) and lower relative skeletal muscle mass (β = - 0.179; 95{\%} CI = - 0.274, - 0.084). Lower albumin levels were significantly associated with lower gait speed (β = - 0.020; 95{\%} CI = - 0.011, - 0.028) and handgrip strength (β = - 0.596; 95{\%} CI = - 0.311, - 0.881). Associations remained significant after adjustment for age, sex and number of morbidities. No significant associations were found for white blood cell count and measures of sarcopenia.CONCLUSIONS: In geriatric outpatients, erythrocyte sedimentation rate was associated with all three measures of sarcopenia, underpinning the potential role of inflammation in sarcopenia.",
author = "{van Atteveld}, {Vera A} and {Van Ancum}, {Jeanine M} and Reijnierse, {Esmee M} and Trappenburg, {Marijke C} and Meskers, {Carel G M} and Maier, {Andrea B}",
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Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia : a cross-sectional study. / van Atteveld, Vera A; Van Ancum, Jeanine M; Reijnierse, Esmee M; Trappenburg, Marijke C; Meskers, Carel G M; Maier, Andrea B.

In: BMC Geriatrics, Vol. 19, No. 1, 233, 27.08.2019, p. 233.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Erythrocyte sedimentation rate and albumin as markers of inflammation are associated with measures of sarcopenia

T2 - a cross-sectional study

AU - van Atteveld, Vera A

AU - Van Ancum, Jeanine M

AU - Reijnierse, Esmee M

AU - Trappenburg, Marijke C

AU - Meskers, Carel G M

AU - Maier, Andrea B

PY - 2019/8/27

Y1 - 2019/8/27

N2 - BACKGROUND: Chronic inflammation is considered to affect physical performance, muscle strength and muscle mass, i.e. measures of sarcopenia. We need to identify a marker of inflammation that is univocally associated with measures of sarcopenia. We aimed to associate three markers of inflammation, erythrocyte sedimentation rate, albumin and white blood cell count, with measures of sarcopenia in geriatric outpatients.METHODS: Data from the Centre Of Geriatrics Amsterdam cohort was used. Geriatric outpatients at the VU university medical centre in Amsterdam were recruited based on referral between January 1st 2014 and the 31st of December 2015. Erythrocyte sedimentation rate, albumin and white blood cell count were assessed from venous blood samples. Measures of sarcopenia included physical performance by measuring gait speed with the 4 meter walk test, duration of the timed up and go test and of the chair stand test, muscle strength by assessing handgrip strength using handheld dynamometry and skeletal muscle mass by performing bioelectrical impedance analysis. Multivariable linear regression analyses were performed to assess the associations between erythrocyte sedimentation rate, albumin, white blood cell count and measures of sarcopenia.RESULTS: A total of 442 patients (mean age 80.8 years, SD 6.7, 58.1% female) were included. A higher erythrocyte sedimentation rate was significantly associated with lower gait speed (β = - 0.005; 95% CI = - 0.007, - 0.003), longer duration of timed up and go test (Ln β = 0.006; 95% CI = 0.003, 0.010), longer duration of chair stand test (Ln β = 0.005; 95% CI = 0.002, 0.008), lower handgrip strength (β = - 0.126; 95% CI = - 0.189, - 0.063) and lower relative skeletal muscle mass (β = - 0.179; 95% CI = - 0.274, - 0.084). Lower albumin levels were significantly associated with lower gait speed (β = - 0.020; 95% CI = - 0.011, - 0.028) and handgrip strength (β = - 0.596; 95% CI = - 0.311, - 0.881). Associations remained significant after adjustment for age, sex and number of morbidities. No significant associations were found for white blood cell count and measures of sarcopenia.CONCLUSIONS: In geriatric outpatients, erythrocyte sedimentation rate was associated with all three measures of sarcopenia, underpinning the potential role of inflammation in sarcopenia.

AB - BACKGROUND: Chronic inflammation is considered to affect physical performance, muscle strength and muscle mass, i.e. measures of sarcopenia. We need to identify a marker of inflammation that is univocally associated with measures of sarcopenia. We aimed to associate three markers of inflammation, erythrocyte sedimentation rate, albumin and white blood cell count, with measures of sarcopenia in geriatric outpatients.METHODS: Data from the Centre Of Geriatrics Amsterdam cohort was used. Geriatric outpatients at the VU university medical centre in Amsterdam were recruited based on referral between January 1st 2014 and the 31st of December 2015. Erythrocyte sedimentation rate, albumin and white blood cell count were assessed from venous blood samples. Measures of sarcopenia included physical performance by measuring gait speed with the 4 meter walk test, duration of the timed up and go test and of the chair stand test, muscle strength by assessing handgrip strength using handheld dynamometry and skeletal muscle mass by performing bioelectrical impedance analysis. Multivariable linear regression analyses were performed to assess the associations between erythrocyte sedimentation rate, albumin, white blood cell count and measures of sarcopenia.RESULTS: A total of 442 patients (mean age 80.8 years, SD 6.7, 58.1% female) were included. A higher erythrocyte sedimentation rate was significantly associated with lower gait speed (β = - 0.005; 95% CI = - 0.007, - 0.003), longer duration of timed up and go test (Ln β = 0.006; 95% CI = 0.003, 0.010), longer duration of chair stand test (Ln β = 0.005; 95% CI = 0.002, 0.008), lower handgrip strength (β = - 0.126; 95% CI = - 0.189, - 0.063) and lower relative skeletal muscle mass (β = - 0.179; 95% CI = - 0.274, - 0.084). Lower albumin levels were significantly associated with lower gait speed (β = - 0.020; 95% CI = - 0.011, - 0.028) and handgrip strength (β = - 0.596; 95% CI = - 0.311, - 0.881). Associations remained significant after adjustment for age, sex and number of morbidities. No significant associations were found for white blood cell count and measures of sarcopenia.CONCLUSIONS: In geriatric outpatients, erythrocyte sedimentation rate was associated with all three measures of sarcopenia, underpinning the potential role of inflammation in sarcopenia.

U2 - 10.1186/s12877-019-1253-5

DO - 10.1186/s12877-019-1253-5

M3 - Article

VL - 19

SP - 233

JO - BMC Geriatrics

JF - BMC Geriatrics

SN - 1471-2318

IS - 1

M1 - 233

ER -