Estimating complex cortical networks via surface recordings-A critical note

L. Antiqueira, F.A. Rodrigues, B.C.M. van Wijk, L. da F. Costa, A. Daffertshofer

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    We discuss potential caveats when estimating topologies of 3D brain networks from surface recordings. It is virtually impossible to record activity from all single neurons in the brain and one has to rely on techniques that measure average activity at sparsely located (non-invasive) recording sites. Effects of this spatial sampling in relation to structural network measures like centrality and assortativity were analyzed using multivariate classifiers. A simplified model of 3D brain connectivity incorporating both short- and long-range connections served for testing. To mimic M/EEG recordings we sampled this model via non-overlapping regions and weighted nodes and connections according to their proximity to the recording sites. We used various complex network models for reference and tried to classify sampled versions of the "brain-like" network as one of these archetypes. It was found that sampled networks may substantially deviate in topology from the respective original networks for small sample sizes. For experimental studies this may imply that surface recordings can yield network structures that might not agree with its generating 3D network. © 2010 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)439-449
    JournalNeuroImage
    Volume53
    Issue number2
    DOIs
    Publication statusPublished - 2010

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