Estimation of individual genetic and environmental profiles in longitudinal designs

D.I. Boomsma, P.C.M. Molenaar, C.V. Dolan

Research output: Contribution to JournalArticleAcademicpeer-review

185 Downloads (Pure)

Abstract

Parameter estimates obtained in the genetic analysis of longitudinal data can be used to construct individual genetic and environmental profiles across time. Such individual profiles enable the attribution of individual phenotypic change to changes in the underlying genetic or environmental processes and may lead to practical applications in genetic counseling and epidemiology. Simulations show that individual estimates of factor scores can be reliably obtained. Decomposition of univariate, and to a lesser extent of bivariate, phenotypic time series may yield estimates of independent individual G(t) and E(t), however, that are intercorrelated. The magnitude of these correlations depends somewhat on the autocorrelation structure of the underlying series, but to obtain completely independent estimates of genetic and environmental individual profiles, at least three measured indicators are needed at each point in time. © 1991 Plenum Publishing Corporation.
Original languageEnglish
Pages (from-to)243-255
JournalBehavior Genetics
Volume21
Issue number3
DOIs
Publication statusPublished - 1991

Fingerprint

Dive into the research topics of 'Estimation of individual genetic and environmental profiles in longitudinal designs'. Together they form a unique fingerprint.

Cite this