Estimation of Subject-Specific Heritabilities From Intra-Individual Variation: iFACE

P.C.M. Molenaar, D.J.A. Smit, D.I. Boomsma, J.R. Nesselroade

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A new genetic factor model for multivariate phenotypic time series, iFACE, is presented which allows for the estimation of subject-specific model parameters of genetic and environmental factors. The iFACE was applied to multivariate EEG registrations obtained with single dizygotic twin pairs. The results showed evidence for considerable subject-specificity in heritabilities and environmental effects. The assumption that the population is homogeneous (i.e., that each case in the population obeys the same parametric model), does not hold for these psychophysiological data, and its use should be critically reconsidered.We conclude that the iFACE provides a powerful new methodology to assess heterogeneity (subject-specificity) based on phenotypic observations. © The Authors 2012.
Original languageEnglish
Pages (from-to)393-400
JournalTwin Research and Human Genetics
Volume15
Issue number3
DOIs
Publication statusPublished - 2012

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