Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal

C.H. Nabuurs; W. Kievit; C.R. Leemans; C.F.G.M. Smit; M.W.M. van den Brekel; R.J. Pauw; B.F.A.M. van der Laan; J.C. Jansen; M. Lacko; W.W. Braunius; C. Dai; X. Shi; G. Danesi; J. Bouček; R.P. Takes; H.P.M. Kunst

doi:10.1002/hed.27082

Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal

C.H. Nabuurs, W. Kievit, C.R. Leemans, C.F.G.M. Smit, M.W.M. van den Brekel, R.J. Pauw, B.F.A.M. van der Laan, J.C. Jansen, M. Lacko, W.W. Braunius, C. Dai, X. Shi, G. Danesi, J. Bouček, R.P. Takes, H.P.M. Kunst

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.Background: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti. Methods: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated. Results: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass. Conclusion: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.

Original language	English
Pages (from-to)	1787-1798
Journal	Head and Neck
Volume	44
Issue number	8
DOIs	https://doi.org/10.1002/hed.27082
Publication status	Published - 1 Aug 2022
Externally published	Yes

Funding

We greatly appreciate and are thankful for the contribution of collecting data by Michaela Tesarova MD (Department of Otorhinolaryngology, Head and Neck Surgery, The First Faculty of Medicine, Charles University in Prague, University Hospital Motol, Prague, Czech Republic) and by Rachele Bivona MD (Department of Otorhinolaryngology and Skull Base Microsurgery-Neurosciences, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy).

Funders	Funder number
Rachele Bivona MD

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Nabuurs, C. H., Kievit, W., Leemans, C. R., Smit, C. F. G. M., van den Brekel, M. W. M., Pauw, R. J., van der Laan, B. F. A. M., Jansen, J. C., Lacko, M., Braunius, W. W., Dai, C., Shi, X., Danesi, G., Bouček, J., Takes, R. P., & Kunst, H. P. M. (2022). Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal. Head and Neck, 44(8), 1787-1798. https://doi.org/10.1002/hed.27082

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abstract = "{\textcopyright} 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.Background: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti. Methods: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated. Results: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass. Conclusion: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.",

author = "C.H. Nabuurs and W. Kievit and C.R. Leemans and C.F.G.M. Smit and {van den Brekel}, M.W.M. and R.J. Pauw and {van der Laan}, B.F.A.M. and J.C. Jansen and M. Lacko and W.W. Braunius and C. Dai and X. Shi and G. Danesi and J. Bou{\v c}ek and R.P. Takes and H.P.M. Kunst",

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Nabuurs, CH, Kievit, W, Leemans, CR, Smit, CFGM, van den Brekel, MWM, Pauw, RJ, van der Laan, BFAM, Jansen, JC, Lacko, M, Braunius, WW, Dai, C, Shi, X, Danesi, G, Bouček, J, Takes, RP & Kunst, HPM 2022, 'Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal', Head and Neck, vol. 44, no. 8, pp. 1787-1798. https://doi.org/10.1002/hed.27082

TY - JOUR

T1 - Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal

AU - Nabuurs, C.H.

AU - Kievit, W.

AU - Leemans, C.R.

AU - Smit, C.F.G.M.

AU - van den Brekel, M.W.M.

AU - Pauw, R.J.

AU - van der Laan, B.F.A.M.

AU - Jansen, J.C.

AU - Lacko, M.

AU - Braunius, W.W.

AU - Dai, C.

AU - Shi, X.

AU - Danesi, G.

AU - Bouček, J.

AU - Takes, R.P.

AU - Kunst, H.P.M.

PY - 2022/8/1

Y1 - 2022/8/1

N2 - © 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.Background: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti. Methods: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated. Results: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass. Conclusion: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.

AB - © 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.Background: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti. Methods: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated. Results: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass. Conclusion: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.

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SN - 1043-3074

VL - 44

SP - 1787

EP - 1798

JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal

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