Evaluation of the modified Pittsburgh classification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal

Cindy H. Nabuurs; Wietske Kievit; Nilou Labbé; C. René Leemans; Conrad F.G.M. Smit; Michiel W.M. van den Brekel; Robert J. Pauw; Bernard F.A.M. van der Laan; Jeroen C. Jansen; Martin Lacko; Weibel W. Braunius; Shinya Morita; Małgorzata Wierzbicka; Takuma Matoba; Nobuhiro Hanai; Robert P. Takes; Henricus P.M. Kunst

doi:10.1002/hed.26424

Evaluation of the modified Pittsburgh classification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal

Cindy H. Nabuurs
, Wietske Kievit
, Nilou Labbé
, C. René Leemans
, Conrad F.G.M. Smit
, Michiel W.M. van den Brekel
, Robert J. Pauw
, Bernard F.A.M. van der Laan
, Jeroen C. Jansen
, Martin Lacko
, Weibel W. Braunius
, Shinya Morita
, Małgorzata Wierzbicka
, Takuma Matoba
, Nobuhiro Hanai
, Robert P. Takes
, Henricus P.M. Kunst

Maxillofacial Surgery (AMC)

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods: We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results: A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion: The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.

Original language	English
Pages (from-to)	3609-3622
Number of pages	14
Journal	Head and Neck
Volume	42
Issue number	12
Early online date	13 Aug 2020
DOIs	https://doi.org/10.1002/hed.26424
Publication status	Published - Dec 2020

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Head & Neck published by Wiley Periodicals LLC.

Funding

The authors thank Gerjon Hannink, PhD, of the Department of Orthopedic Research Laboratory at Radboud University Medical Center for his assistance with statistical analysis. The authors thank Michael G. Moore MD, PhD (patient data coming from the Massachusetts Eye and Ear Infirmary, Boston MA), Luc G. T. Morris MD, MSc, Saral Mehra MD, MBA, Hirotaka Shinomiya MD, PhD, Hisashi Sugimoto MD, PhD, Wandee Khaimook MD and José L. Llorente MD, PhD, for their contribution by providing their individual patient data of their studies.

Funders	Funder number
Michael G. Moore MD
Massachusetts Eye and Ear Infirmary
Japan Society for the Promotion of Science	19K18779

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1002/hed.26424

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Nabuurs, C. H., Kievit, W., Labbé, N., Leemans, C. R., Smit, C. F. G. M., van den Brekel, M. W. M., Pauw, R. J., van der Laan, B. F. A. M., Jansen, J. C., Lacko, M., Braunius, W. W., Morita, S., Wierzbicka, M., Matoba, T., Hanai, N., Takes, R. P., & Kunst, H. P. M. (2020). Evaluation of the modified Pittsburgh classification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal. Head and Neck, 42(12), 3609-3622. https://doi.org/10.1002/hed.26424

@article{129d9b519e0144d9ad466b9ae001c208,

title = "Evaluation of the modified Pittsburgh classification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal",

abstract = "Background: Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods: We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results: A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion: The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.",

author = "Nabuurs, \{Cindy H.\} and Wietske Kievit and Nilou Labb{\'e} and Leemans, \{C. Ren{\'e}\} and Smit, \{Conrad F.G.M.\} and \{van den Brekel\}, \{Michiel W.M.\} and Pauw, \{Robert J.\} and \{van der Laan\}, \{Bernard F.A.M.\} and Jansen, \{Jeroen C.\} and Martin Lacko and Braunius, \{Weibel W.\} and Shinya Morita and Ma{\l}gorzata Wierzbicka and Takuma Matoba and Nobuhiro Hanai and Takes, \{Robert P.\} and Kunst, \{Henricus P.M.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Head \& Neck published by Wiley Periodicals LLC.",

year = "2020",

month = dec,

doi = "10.1002/hed.26424",

language = "English",

volume = "42",

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Nabuurs, CH, Kievit, W, Labbé, N, Leemans, CR, Smit, CFGM, van den Brekel, MWM, Pauw, RJ, van der Laan, BFAM, Jansen, JC, Lacko, M, Braunius, WW, Morita, S, Wierzbicka, M, Matoba, T, Hanai, N, Takes, RP & Kunst, HPM 2020, 'Evaluation of the modified Pittsburgh classification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal', Head and Neck, vol. 42, no. 12, pp. 3609-3622. https://doi.org/10.1002/hed.26424

TY - JOUR

T1 - Evaluation of the modified Pittsburgh classification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal

AU - Nabuurs, Cindy H.

AU - Kievit, Wietske

AU - Labbé, Nilou

AU - Leemans, C. René

AU - Smit, Conrad F.G.M.

AU - van den Brekel, Michiel W.M.

AU - Pauw, Robert J.

AU - van der Laan, Bernard F.A.M.

AU - Jansen, Jeroen C.

AU - Lacko, Martin

AU - Braunius, Weibel W.

AU - Morita, Shinya

AU - Wierzbicka, Małgorzata

AU - Matoba, Takuma

AU - Hanai, Nobuhiro

AU - Takes, Robert P.

AU - Kunst, Henricus P.M.

PY - 2020/12

Y1 - 2020/12

N2 - Background: Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods: We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results: A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion: The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.

AB - Background: Squamous cell carcinoma (SCC) of the external auditory canal (EAC) is a rare disease, which is commonly classified with the modified Pittsburgh classification. Our aim was to evaluate the predictive performance of this classification in relation to disease-free survival (DFS). Methods: We examined retrospective data from a nationwide Dutch cohort study including patients with primary EAC SCC. These data were combined with individual patient data from the literature. Using the combined data, the predictive performances were calculated using the c-index. Results: A total of 381 patients were included, 294 for clinical and 281 for the pathological classification analyses. The c-indices of the clinical and the pathological modified Pittsburgh classification predicting DFS were 0.725 (0.668-0.782) and 0.729 (0.672-0.786), respectively. Conclusion: The predictive performance of the modified Pittsburgh classification system as such appears to be acceptable to predict the DFS of EAC SCC. Other factors need to be added to a future model to improve the predicted performance.

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SN - 1043-3074

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SP - 3609

EP - 3622

JO - Head and Neck

JF - Head and Neck

IS - 12

ER -

Evaluation of the modified Pittsburgh classification for predicting the disease-free survival outcome of squamous cell carcinoma of the external auditory canal

Abstract

Bibliographical note

Funding

UN SDGs

Access to Document

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