Evidence-based analysis of neurotransmitter modulation by gut microbiota

Ting Liu, Zhisheng Huang*

*Corresponding author for this work

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Abstract

Gut microbiota that lives in the human gastrointestinal tract impacts on the mental illness through the neurotransmitter-mediated pathway. It’s well known that the imbalance of neurotransmitter leads to mental problems. The association between gut microbiota and neurotransmitter needs to be explored in depth. In this paper, we aim at identifying the quality evidence of neurotransmitter modulation by gut microbiota. We use evidence-based medical analysis to characterize the relevant articles to five levels in terms of the strength and reliability of evidence. Thirty-four articles are identified to evaluate their evidence. Gut microbiota not only produces neurotransmitters directly but also modulates neurotransmitters level via metabolism pathways. Also, the growth of some gut microbiota can be counter-regulated by neurotransmitters. This paper provides a comprehensive picture of the association between gut microbiota and neurotransmitter, which give researchers an insight into neurotransmitter modulation by gut microbiota.

Original languageEnglish
Title of host publicationHealth Information Science
Subtitle of host publication8th International Conference, HIS 2019, Xi’an, China, October 18–20, 2019, Proceedings
EditorsHua Wang, Siuly Siuly, Yanchun Zhang, Rui Zhou, Fernando Martin-Sanchez, Zhisheng Huang
PublisherSpringer
Pages238-249
Number of pages12
ISBN (Electronic)9783030329624
ISBN (Print)9783030329617
DOIs
Publication statusPublished - 2019
Event8th International Conference on Health Information Science, HIS 2019 - Xi'an, China
Duration: 18 Oct 201920 Oct 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11837 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference8th International Conference on Health Information Science, HIS 2019
CountryChina
CityXi'an
Period18/10/1920/10/19

Keywords

  • Dopamine
  • Evidence-based analysis
  • GABA
  • Gut microbiota
  • Level of evidence
  • Neurotransmitter
  • Norepinephrine
  • Serotonin

Fingerprint

Dive into the research topics of 'Evidence-based analysis of neurotransmitter modulation by gut microbiota'. Together they form a unique fingerprint.

Cite this