Exercise, fasting, and mimetics: Toward beneficial combinations?

Richard T. Jaspers, M Carola Zillikens, Edith C H Friesema, Giuseppe Delli Paoli, Wilhelm Bloch, André G Uitterlinden, Fernando Goglia, Antonia Lanni, Pieter De Lange*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

60 Downloads (Pure)

Abstract

Obesity and type 2 diabetes are associated disorders that involve a multiplicity of tissues. Both fasting and physical exercise are known to counteract dyslipidemia/hyperglycemia. Skeletal muscle plays a key role in the control of blood glucose levels, and the metabolic changes and related signaling pathways in skeletal muscle induced by fasting overlap with those induced by exercise. The reduction of fat disposal has been shown to extend to the liver and to white and brown adipose tissue and to involve an increase in their metabolic activities. In recent years signal transduction pathways related to exercise and fasting/food withdrawal in muscle have been intensively studied, both in animals and in humans. Combining fasting/food withdrawal with exercise in animals aswell as in humans causes changes unlike those seen during fasting/food withdrawal or exercise alone, which favor repair of muscle over autophagy. In addition, compounds that mimic exercise have been studied in combination with exercise or fasting/food with drawal. This review addresses our current knowledge of the mechanisms that underlie the individual and combined effects of fasting/food withdrawal, endurance or resistance exercise, and their mimetics, in muscle vs. other organs in rodents and humans, and highlights which combinations may improve metabolic disorders. -Jaspers, R. T., Zillikens, M. C., Friesema, E. C. H., delli Paoli, G., Bloch, W., Uitterlinden, A. G., Goglia, F., Lanni, A., de Lange, P. Exercise, fasting, and mimetics: toward beneficial combinations.

Original languageEnglish
Pages (from-to)14-28
Number of pages15
JournalFASEB Journal
Volume31
Issue number1
Early online date11 Oct 2016
DOIs
Publication statusPublished - Jan 2017

Keywords

  • Metabolic syndrome
  • Signal transduction
  • Skeletal muscle

Fingerprint

Dive into the research topics of 'Exercise, fasting, and mimetics: Toward beneficial combinations?'. Together they form a unique fingerprint.

Cite this