Exercise therapy for fatigue in multiple sclerosis

M. Heine, I. van de Port, M.B. Rietberg, E.E.H. van Wegen, G. Kwakkel

    Research output: Contribution to JournalArticleAcademicpeer-review


    BACKGROUND: Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system affecting an estimated 1.3 million people worldwide. It is characterised by a variety of disabling symptoms of which excessive fatigue is the most frequent. Fatigue is often reported as the most invalidating symptom in people with MS. Various mechanisms directly and indirectly related to the disease and physical inactivity have been proposed to contribute to the degree of fatigue. Exercise therapy can induce physiological and psychological changes that may counter these mechanisms and reduce fatigue in MS.
    Original languageEnglish
    Article numberCD009956
    JournalCochrane Database of Systematic Reviews
    Issue number9
    Publication statusPublished - 11 Sep 2015


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