@article{ad08bfd9764144b7a3d9ba15079f3860,
title = "Exploring the genetic correlations of antisocial behaviour and life history traits",
abstract = "Prior evolutionary theory provided reason to suspect that measures of development and reproduction would be correlated with antisocial behaviours in human and non-human species. Behavioural genetics has revealed that most quantitative traits are heritable, suggesting that these phenotypic correlations may share genetic aetiologies. We use genome-wide association study data to estimate the genetic correlations between various measures of reproductive development (N = 52 776-318 863) and antisocial behaviour (N = 31 968). Our genetic correlation analyses demonstrate that alleles associated with higher reproductive output (number of children ever born, r g = 0.50, P = 0.0065) were positively correlated with alleles associated with antisocial behaviour, whereas alleles associated with more delayed reproductive onset (age at first birth, r g = -0.64, P = 0.0008) were negatively associated with alleles linked to antisocial behaviour. Ultimately, these findings coalesce with evolutionary theories suggesting that increased antisocial behaviours may partly represent a faster life history approach, which may be significantly calibrated by genes.",
keywords = "antisocial behaviour, Genome-wide association study, linkage disequilibrium regression",
author = "Tielbeek, {Jorim J.} and Barnes, {J. C.} and Arne Popma and Polderman, {Tinca J.C.} and Lee, {James J.} and Perry, {John R.B.} and Danielle Posthuma and Boutwell, {Brian B.}",
year = "2018",
doi = "10.1192/bjo.2018.63",
language = "English",
volume = "4",
pages = "467--470",
journal = "BJPsych Open",
issn = "2056-4724",
publisher = "Cambridge University Press",
number = "6",
}