TY - JOUR
T1 - Exploring the Genomic Architectures of Health, Physical Traits and Antisocial Behavioral Outcomes
T2 - A Brief Report
AU - Tielbeek, Jorim J.
AU - Boutwell, Brian B.
PY - 2020/6/25
Y1 - 2020/6/25
N2 - A widely replicated finding across the behavioral sciences is that antisocial behaviors correlate with an array of health problems. Less clear, however, is the precise nature of this association. There is reason to suspect that a direct causal link exists between incarceration—a consequence of some antisocial behaviors—and certain negative health outcomes, for instance. However, it might be the case that broader phenotypes like antisocial behavior may correlate with certain health and physiological traits at a genomic level. We explore this possibility from a theoretical vantage point, while also presenting some preliminary data from existing secondary sources. Tentatively, no significant genetic correlations emerged across a host of health, physiological, and wellbeing outcomes after correction for multiple testing. However, more work is needed exploring this topic. We propose that future studies should make use of larger, more diverse samples and examine the genetic overlap between homogeneous clusters of antisocial behavioral subtypes and disease traits or symptoms.
AB - A widely replicated finding across the behavioral sciences is that antisocial behaviors correlate with an array of health problems. Less clear, however, is the precise nature of this association. There is reason to suspect that a direct causal link exists between incarceration—a consequence of some antisocial behaviors—and certain negative health outcomes, for instance. However, it might be the case that broader phenotypes like antisocial behavior may correlate with certain health and physiological traits at a genomic level. We explore this possibility from a theoretical vantage point, while also presenting some preliminary data from existing secondary sources. Tentatively, no significant genetic correlations emerged across a host of health, physiological, and wellbeing outcomes after correction for multiple testing. However, more work is needed exploring this topic. We propose that future studies should make use of larger, more diverse samples and examine the genetic overlap between homogeneous clusters of antisocial behavioral subtypes and disease traits or symptoms.
KW - antisocial behavior
KW - comorbidity
KW - disease traits
KW - genetic correlation analysis
KW - genome wide association analysis
UR - http://www.scopus.com/inward/record.url?scp=85087699189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85087699189&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2020.00539
DO - 10.3389/fpsyt.2020.00539
M3 - Article
AN - SCOPUS:85087699189
SN - 1664-0640
VL - 11
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
M1 - 539
ER -