Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future

Morgane Mitermite, Jose Maria Urtasun Elizari, Ruoyao Ma, Damien Farrell, Stephen V. Gordon*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.

Original languageEnglish
Article number26
Pages (from-to)1-9
Number of pages9
JournalIrish Veterinary Journal
Volume76
Issue numbersuppl 1
Early online date28 Sept 2023
DOIs
Publication statusPublished - 2023

Bibliographical note

Funding Information:
Work described in this manuscript was supported by the Wellcome Trust (PhD studentship 109166/Z/15/A to MM), Science Foundation Ireland (SFI/15/IA/3154 to SG and JMUE), Department of Agriculture Food and the Marine (DAFM) award 2019R404 (BTBGenIE to SG and DF), and the China Scholarship Council (CSC to RM). Funding bodies had no role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2023, The Author(s).

Funding

Work described in this manuscript was supported by the Wellcome Trust (PhD studentship 109166/Z/15/A to MM), Science Foundation Ireland (SFI/15/IA/3154 to SG and JMUE), Department of Agriculture Food and the Marine (DAFM) award 2019R404 (BTBGenIE to SG and DF), and the China Scholarship Council (CSC to RM). Funding bodies had no role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript.

Keywords

  • Genomics
  • Mycobacterium bovis
  • TB
  • Tuberculosis
  • Virulence

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