Abstract
Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.
Original language | English |
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Article number | 26 |
Pages (from-to) | 1-9 |
Number of pages | 9 |
Journal | Irish Veterinary Journal |
Volume | 76 |
Issue number | suppl 1 |
Early online date | 28 Sept 2023 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Funding Information:Work described in this manuscript was supported by the Wellcome Trust (PhD studentship 109166/Z/15/A to MM), Science Foundation Ireland (SFI/15/IA/3154 to SG and JMUE), Department of Agriculture Food and the Marine (DAFM) award 2019R404 (BTBGenIE to SG and DF), and the China Scholarship Council (CSC to RM). Funding bodies had no role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2023, The Author(s).
Funding
Work described in this manuscript was supported by the Wellcome Trust (PhD studentship 109166/Z/15/A to MM), Science Foundation Ireland (SFI/15/IA/3154 to SG and JMUE), Department of Agriculture Food and the Marine (DAFM) award 2019R404 (BTBGenIE to SG and DF), and the China Scholarship Council (CSC to RM). Funding bodies had no role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript.
Keywords
- Genomics
- Mycobacterium bovis
- TB
- Tuberculosis
- Virulence