Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future

Morgane Mitermite; Jose Maria Urtasun Elizari; Ruoyao Ma; Damien Farrell; Stephen V. Gordon

doi:10.1186/s13620-023-00257-6

Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future

Morgane Mitermite
, Jose Maria Urtasun Elizari
, Ruoyao Ma
, Damien Farrell
, Stephen V. Gordon^*

^*Corresponding author for this work

Computer Science

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.

Original language	English
Article number	26
Pages (from-to)	1-9
Number of pages	9
Journal	Irish Veterinary Journal
Volume	76
Issue number	1 supplement
DOIs	https://doi.org/10.1186/s13620-023-00257-6
Publication status	Published - Jul 2023

Bibliographical note

Publoshed online: 28 september 2023.

Publisher Copyright:
© 2023, The Author(s).

Funding

Work described in this manuscript was supported by the Wellcome Trust (PhD studentship 109166/Z/15/A to MM), Science Foundation Ireland (SFI/15/IA/3154 to SG and JMUE), Department of Agriculture Food and the Marine (DAFM) award 2019R404 (BTBGenIE to SG and DF), and the China Scholarship Council (CSC to RM). Funding bodies had no role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript.

Funders	Funder number
China Scholarship Council
Wellcome Trust	109166/Z/15/A, 109166
Science Foundation Ireland	SFI/15/IA/3154
Department of Agriculture, Food and the Marine, Ireland	2019R404

Keywords

Genomics
Mycobacterium bovis
TB
Tuberculosis
Virulence

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10.1186/s13620-023-00257-6

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Cite this

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title = "Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future",

abstract = "Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.",

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author = "Morgane Mitermite and Elizari, \{Jose Maria Urtasun\} and Ruoyao Ma and Damien Farrell and Gordon, \{Stephen V.\}",

note = "Publoshed online: 28 september 2023. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

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doi = "10.1186/s13620-023-00257-6",

language = "English",

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AU - Mitermite, Morgane

AU - Elizari, Jose Maria Urtasun

AU - Ma, Ruoyao

AU - Farrell, Damien

AU - Gordon, Stephen V.

PY - 2023/7

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N2 - Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.

AB - Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.

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KW - Mycobacterium bovis

KW - TB

KW - Tuberculosis

KW - Virulence

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DO - 10.1186/s13620-023-00257-6

M3 - Review article

AN - SCOPUS:85173104032

SN - 0368-0762

VL - 76

SP - 1

EP - 9

JO - Irish Veterinary Journal

JF - Irish Veterinary Journal

IS - 1 supplement

M1 - 26

ER -

Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future

Abstract

Bibliographical note

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Keywords

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