Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study

L. Malan, M. Hamer, M.P. Schlaich, G.W. Lambert, B.H. Harvey, M. Reimann, T. Ziemssen, E.J.C. de Geus, H.W. Huisman, J.M. van Rooyen, R. Schutte, A.E. Schutte, C.M.T. Fourie, Y.K. Seedat, N.T. Malan

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: Defensive active coping responses (being-in-control, acceptance of the stressor as reality) have been associated with vascular hyper-responsiveness in urban Africans. However, the association between active coping responses, blood pressure (BP), and ECG-derived left-ventricular hypertrophy (LVH) responses is unknown. OBJECTIVES AND Methods: Associations between BP, silent ischaemia and ECG Cornell product LVH were assessed in 161 African and Caucasian men with active coping responses identified by the Amirkhan Coping Strategy Indicator. BP, ECG and silent ischaemia data were obtained from 24-h ambulatory monitoring. Beat-to-beat BP was continuously recorded during stress testing and fasting resting blood samples obtained for biochemical analyses. Results: Enhanced ß-adrenergic central cardiac responses were evident in active coping Caucasians as opposed to a predomination of α-adrenergic vascular responses in active coping Africans. Active coping African men displayed higher 24-h BP and prevalence of silent ischaemia events compared to the Caucasian men. Regression analyses revealed that α-adrenergic responses were associated with silent ischaemic events, adjusted R
Original languageEnglish
Pages (from-to)543-550
JournalJournal of Hypertension
Volume30
Issue number3
DOIs
Publication statusPublished - 2012

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Left Ventricular Hypertrophy
Electrocardiography
Ischemia
Blood Pressure
Adrenergic Agents
Blood Vessels
Ambulatory Monitoring
Fasting
Regression Analysis

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Malan, L., Hamer, M., Schlaich, M. P., Lambert, G. W., Harvey, B. H., Reimann, M., ... Malan, N. T. (2012). Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study. Journal of Hypertension, 30(3), 543-550. https://doi.org/10.1097/HJH.0b013e32834fcf82
Malan, L. ; Hamer, M. ; Schlaich, M.P. ; Lambert, G.W. ; Harvey, B.H. ; Reimann, M. ; Ziemssen, T. ; de Geus, E.J.C. ; Huisman, H.W. ; van Rooyen, J.M. ; Schutte, R. ; Schutte, A.E. ; Fourie, C.M.T. ; Seedat, Y.K. ; Malan, N.T. / Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study. In: Journal of Hypertension. 2012 ; Vol. 30, No. 3. pp. 543-550.
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title = "Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study",
abstract = "Background: Defensive active coping responses (being-in-control, acceptance of the stressor as reality) have been associated with vascular hyper-responsiveness in urban Africans. However, the association between active coping responses, blood pressure (BP), and ECG-derived left-ventricular hypertrophy (LVH) responses is unknown. OBJECTIVES AND Methods: Associations between BP, silent ischaemia and ECG Cornell product LVH were assessed in 161 African and Caucasian men with active coping responses identified by the Amirkhan Coping Strategy Indicator. BP, ECG and silent ischaemia data were obtained from 24-h ambulatory monitoring. Beat-to-beat BP was continuously recorded during stress testing and fasting resting blood samples obtained for biochemical analyses. Results: Enhanced {\ss}-adrenergic central cardiac responses were evident in active coping Caucasians as opposed to a predomination of α-adrenergic vascular responses in active coping Africans. Active coping African men displayed higher 24-h BP and prevalence of silent ischaemia events compared to the Caucasian men. Regression analyses revealed that α-adrenergic responses were associated with silent ischaemic events, adjusted R",
author = "L. Malan and M. Hamer and M.P. Schlaich and G.W. Lambert and B.H. Harvey and M. Reimann and T. Ziemssen and {de Geus}, E.J.C. and H.W. Huisman and {van Rooyen}, J.M. and R. Schutte and A.E. Schutte and C.M.T. Fourie and Y.K. Seedat and N.T. Malan",
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Malan, L, Hamer, M, Schlaich, MP, Lambert, GW, Harvey, BH, Reimann, M, Ziemssen, T, de Geus, EJC, Huisman, HW, van Rooyen, JM, Schutte, R, Schutte, AE, Fourie, CMT, Seedat, YK & Malan, NT 2012, 'Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study' Journal of Hypertension, vol. 30, no. 3, pp. 543-550. https://doi.org/10.1097/HJH.0b013e32834fcf82

Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study. / Malan, L.; Hamer, M.; Schlaich, M.P.; Lambert, G.W.; Harvey, B.H.; Reimann, M.; Ziemssen, T.; de Geus, E.J.C.; Huisman, H.W.; van Rooyen, J.M.; Schutte, R.; Schutte, A.E.; Fourie, C.M.T.; Seedat, Y.K.; Malan, N.T.

In: Journal of Hypertension, Vol. 30, No. 3, 2012, p. 543-550.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study

AU - Malan, L.

AU - Hamer, M.

AU - Schlaich, M.P.

AU - Lambert, G.W.

AU - Harvey, B.H.

AU - Reimann, M.

AU - Ziemssen, T.

AU - de Geus, E.J.C.

AU - Huisman, H.W.

AU - van Rooyen, J.M.

AU - Schutte, R.

AU - Schutte, A.E.

AU - Fourie, C.M.T.

AU - Seedat, Y.K.

AU - Malan, N.T.

PY - 2012

Y1 - 2012

N2 - Background: Defensive active coping responses (being-in-control, acceptance of the stressor as reality) have been associated with vascular hyper-responsiveness in urban Africans. However, the association between active coping responses, blood pressure (BP), and ECG-derived left-ventricular hypertrophy (LVH) responses is unknown. OBJECTIVES AND Methods: Associations between BP, silent ischaemia and ECG Cornell product LVH were assessed in 161 African and Caucasian men with active coping responses identified by the Amirkhan Coping Strategy Indicator. BP, ECG and silent ischaemia data were obtained from 24-h ambulatory monitoring. Beat-to-beat BP was continuously recorded during stress testing and fasting resting blood samples obtained for biochemical analyses. Results: Enhanced ß-adrenergic central cardiac responses were evident in active coping Caucasians as opposed to a predomination of α-adrenergic vascular responses in active coping Africans. Active coping African men displayed higher 24-h BP and prevalence of silent ischaemia events compared to the Caucasian men. Regression analyses revealed that α-adrenergic responses were associated with silent ischaemic events, adjusted R

AB - Background: Defensive active coping responses (being-in-control, acceptance of the stressor as reality) have been associated with vascular hyper-responsiveness in urban Africans. However, the association between active coping responses, blood pressure (BP), and ECG-derived left-ventricular hypertrophy (LVH) responses is unknown. OBJECTIVES AND Methods: Associations between BP, silent ischaemia and ECG Cornell product LVH were assessed in 161 African and Caucasian men with active coping responses identified by the Amirkhan Coping Strategy Indicator. BP, ECG and silent ischaemia data were obtained from 24-h ambulatory monitoring. Beat-to-beat BP was continuously recorded during stress testing and fasting resting blood samples obtained for biochemical analyses. Results: Enhanced ß-adrenergic central cardiac responses were evident in active coping Caucasians as opposed to a predomination of α-adrenergic vascular responses in active coping Africans. Active coping African men displayed higher 24-h BP and prevalence of silent ischaemia events compared to the Caucasian men. Regression analyses revealed that α-adrenergic responses were associated with silent ischaemic events, adjusted R

U2 - 10.1097/HJH.0b013e32834fcf82

DO - 10.1097/HJH.0b013e32834fcf82

M3 - Article

VL - 30

SP - 543

EP - 550

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 3

ER -