Familial searching

Ronald Meester; K Slooten

doi:10.1002/9780470061589.fsa1122

Familial searching

Mathematics

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Abstract

Familial searching is the act of deliberately searching a DNA database with the purpose of identifying biological relatives of the unknown donor of a DNA profile. In this article, we discuss the statistical and probabilistic issues arising from such a search. We first discuss the genetic background of familial searching and observe that some DNA profiles are more suitable for familial searching than others. We discuss various strategies for finding relatives and discuss weak and strong points of each strategy in terms of false positive and false negative rates, workload, and efficiency. We also discuss statistical issues in the context of familial searching arising from the fact that databases and populations are both heterogeneous. Finally, we briefly discuss some ethical issues.

Original language	English
Title of host publication	Wiley Encyclopedia of Forensic Science
Editors	Allan Jamieson, Andre Moenssens
Publisher	Wiley
ISBN (Electronic)	9780470061589
ISBN (Print)	9780470018262
DOIs	https://doi.org/10.1002/9780470061589.fsa1122
Publication status	Published - 2016

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Paper book (5 volume set) first published in June 2009.

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10.1002/9780470061589.fsa1122

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title = "Familial searching",

abstract = "Familial searching is the act of deliberately searching a DNA database with the purpose of identifying biological relatives of the unknown donor of a DNA profile. In this article, we discuss the statistical and probabilistic issues arising from such a search. We first discuss the genetic background of familial searching and observe that some DNA profiles are more suitable for familial searching than others. We discuss various strategies for finding relatives and discuss weak and strong points of each strategy in terms of false positive and false negative rates, workload, and efficiency. We also discuss statistical issues in the context of familial searching arising from the fact that databases and populations are both heterogeneous. Finally, we briefly discuss some ethical issues.",

author = "Ronald Meester and K Slooten",

note = "Paper book (5 volume set) first published in June 2009.",

year = "2016",

doi = "10.1002/9780470061589.fsa1122",

language = "English",

isbn = "9780470018262",

editor = "Allan Jamieson and Andre Moenssens",

booktitle = "Wiley Encyclopedia of Forensic Science",

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T1 - Familial searching

AU - Meester, Ronald

AU - Slooten, K

N1 - Paper book (5 volume set) first published in June 2009.

PY - 2016

Y1 - 2016

N2 - Familial searching is the act of deliberately searching a DNA database with the purpose of identifying biological relatives of the unknown donor of a DNA profile. In this article, we discuss the statistical and probabilistic issues arising from such a search. We first discuss the genetic background of familial searching and observe that some DNA profiles are more suitable for familial searching than others. We discuss various strategies for finding relatives and discuss weak and strong points of each strategy in terms of false positive and false negative rates, workload, and efficiency. We also discuss statistical issues in the context of familial searching arising from the fact that databases and populations are both heterogeneous. Finally, we briefly discuss some ethical issues.

AB - Familial searching is the act of deliberately searching a DNA database with the purpose of identifying biological relatives of the unknown donor of a DNA profile. In this article, we discuss the statistical and probabilistic issues arising from such a search. We first discuss the genetic background of familial searching and observe that some DNA profiles are more suitable for familial searching than others. We discuss various strategies for finding relatives and discuss weak and strong points of each strategy in terms of false positive and false negative rates, workload, and efficiency. We also discuss statistical issues in the context of familial searching arising from the fact that databases and populations are both heterogeneous. Finally, we briefly discuss some ethical issues.

UR - https://onlinelibrary.wiley.com/doi/book/10.1002/9780470061589

U2 - 10.1002/9780470061589.fsa1122

DO - 10.1002/9780470061589.fsa1122

M3 - Entry for encyclopedia/dictionary

SN - 9780470018262

BT - Wiley Encyclopedia of Forensic Science

A2 - Jamieson, Allan

A2 - Moenssens, Andre

PB - Wiley

ER -

Familial searching

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