Family based association analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression

C.M. Middeldorp, E.J.C. de Geus, A.L. Beem, N. Lakenberg, J.J. Hottenga, P.E. Slagboom, D.I. Boomsma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

We studied the association between the short/long promotor-based length polymorphism of the serotonin transporter gene (5-HTTLPR) and neuroticism, anxiety and depression. Subjects included twins, their siblings and parents from the Netherlands Twin Register (559 parents and 1,245 offspring). Subjects had participated between one and five times in a survey study measuring neuroticism, anxiety and depression. Offspring of these families were also approached to participate in a psychiatric interview diagnosing DSM-IV major depression. Within-family and total association between 5-HTTLPR and these traits were tested. Only three of the 36 tests showed a significant effect of 5-HTTLPR (P < 0.05). These effects were in opposite directions, i.e. both negative and positive regression coefficients were found for the s allele. No additive effect of the s allele was found for DSM-IV depression. Our results strongly suggest that there is no straightforward association between 5-HTTLPR and neuroticism, anxiety and depression. © 2007 Springer Science+Business Media, LLC.
Original languageEnglish
Pages (from-to)294-301
JournalBehavior Genetics
Volume37
Issue number2
DOIs
Publication statusPublished - 2007

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Serotonin Plasma Membrane Transport Proteins
anxiety
serotonin
transporters
polymorphism
Anxiety
genetic polymorphism
Depression
gene
allele
Genes
alleles
genes
Diagnostic and Statistical Manual of Mental Disorders
additive effect
Alleles
interviews
Netherlands
Psychiatry
Neuroticism

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title = "Family based association analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression",
abstract = "We studied the association between the short/long promotor-based length polymorphism of the serotonin transporter gene (5-HTTLPR) and neuroticism, anxiety and depression. Subjects included twins, their siblings and parents from the Netherlands Twin Register (559 parents and 1,245 offspring). Subjects had participated between one and five times in a survey study measuring neuroticism, anxiety and depression. Offspring of these families were also approached to participate in a psychiatric interview diagnosing DSM-IV major depression. Within-family and total association between 5-HTTLPR and these traits were tested. Only three of the 36 tests showed a significant effect of 5-HTTLPR (P < 0.05). These effects were in opposite directions, i.e. both negative and positive regression coefficients were found for the s allele. No additive effect of the s allele was found for DSM-IV depression. Our results strongly suggest that there is no straightforward association between 5-HTTLPR and neuroticism, anxiety and depression. {\circledC} 2007 Springer Science+Business Media, LLC.",
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Family based association analyses between the Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Neuroticism, Anxiety and Depression. / Middeldorp, C.M.; de Geus, E.J.C.; Beem, A.L.; Lakenberg, N.; Hottenga, J.J.; Slagboom, P.E.; Boomsma, D.I.

In: Behavior Genetics, Vol. 37, No. 2, 2007, p. 294-301.

Research output: Contribution to JournalArticleAcademicpeer-review

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