Farnesol and Candida albicans: quorum sensing or not quorum sensing?

B.P. Krom, N. Levy, M.M. Meijler, M.A. Jabra-Rizk

Research output: Contribution to JournalArticleAcademicpeer-review


Quorum sensing (QS) molecules function within communities of single-cell organisms to allow concerted behavior in response to changing conditions, and certain criteria have been established to determine whether a particular molecule is quorum sensing or not. Farnesol has been identified as a secreted molecule responsible for the inoculum size effect in Candida albicans and synthetic farnesol has been used as a QS molecule in different studies. However, farnesol also exhibits growth inhibitory effects, and so a critical evaluation of farnesol is warranted. Here we review the literature to determine whether or not farnesol can indeed be considered a QS molecule in C. albicans.
Original languageEnglish
Pages (from-to)295-301
JournalIsrael Journal of Chemistry
Issue number5
Publication statusPublished - 2016


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