Fast comprehensive two-dimensional gas chromatography (GC x GC) using 50-mu m ID second-dimension columns

M. Adahchour, A. Tasoz, J. Beens, R.J.J. Vreuls, A.M. Batenburg, U.A.T. Brinkman

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Up till now, comprehensive two-dimensional gas chromatography has suffered from the serious disadvantage that the first-dimension separation has to be operated both at sub-optimum flow and at slow temperature programming rates to enable the required number of modulations across a first-dimension peak. Consequently, the separation efficiency of the first-dimension is (far) below optimum and the overall analysis times become longer than necessary. This problem can be solved by selecting a short 50-μm ID second-dimension column, and combining it with a standard long 250-μm ID first-dimension column. Compared with conventional GC × GC set-ups, an over 3-fold reduction of the analysis time was reached in the present study without sacrificing resolution; to the contrary, a substantial increase of the peak capacity was obtained.
Original languageEnglish
Pages (from-to)753-760
JournalJournal of Separation Science
Volume26
Issue number9-10
DOIs
Publication statusPublished - 2003

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