Fast, ultrasensitive virus detection using a Young interferometer sensor

Aurel Ymeti, Jan Greve, Paul V Lambeck, Thijs Wink, Stephan W F M van Hövell, Tom A M Beumer, Robert R Wijn, Rene G Heideman, Vinod Subramaniam, Johannes S Kanger

    Research output: Contribution to JournalArticleAcademicpeer-review


    We report the application of an integrated optical Young interferometer sensor for ultrasensitive, real-time, direct detection of viruses. We have validated the sensor by detecting herpes simplex virus type 1 (HSV-1), but the principle is generally applicable. Detection of HSV-1 virus particles was performed by applying the virus sample onto a sensor surface coated with a specific antibody against HSV-1. The performance of the sensor was tested by monitoring virus samples at clinically relevant concentrations. We show that the Young interferometer sensor can specifically and sensitively detect HSV-1 at very low concentrations (850 particles/mL). We have further demonstrated that the sensor can specifically detect HSV-1 suspended in serum. Extrapolation of the results indicates that the sensitivity of the sensor approaches the detection of a single virus particle binding, yielding a sensor of unprecedented sensitivity with wide applications for viral diagnostics.

    Original languageEnglish
    Pages (from-to)394-7
    Number of pages4
    JournalNano Letters
    Issue number2
    Publication statusPublished - Feb 2007


    • Antibodies, Viral
    • Blood
    • Herpesvirus 1, Human
    • Humans
    • Interferometry
    • Nanotechnology
    • Sensitivity and Specificity
    • Virology
    • Viruses
    • Journal Article
    • Research Support, Non-U.S. Gov't


    Dive into the research topics of 'Fast, ultrasensitive virus detection using a Young interferometer sensor'. Together they form a unique fingerprint.

    Cite this