Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: The Baltimore longitudinal study on aging

J. C. Seidell*, D C Muller, J D Sorkin, R. Andres

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The authors followed 775 men (aged 18-98 years) participating in the Baltimore Longitudinal Study in Aging for an average of ten years. Resting metabolic rate and fasting respiratory exchange ratio (RER) were measured by indirect calorimetry on their first visit and related to subsequent weight change. Deviations from the predicted value of resting metabolic rates (predicted from their estimated fat-free mass) were calculated. Average weight change was 0.07kg (s.d. 6.4kg), 122 men (15.3%) gained more than 5 kg and 40 (5.2%) more than 10 kg during the follow-up. After adjustment for initial age, body mass index, fat-free mass, and duration of follow-up, RER, but not RMR or deviations from predicted RMR, was positively related to weight change (P < 0.001). Major weight gain (from at least 5 kg to at least 15 kg) was related to initial RER in non-obese men only (initial body mass index <25 kgm2). From Cox proportional hazard regression analyses the adjusted relative risk of gaining 5 kg or more in initially non-obese men with a fasting RER of 0.85 or more was calculated to be 2.42 (95% confidence interval: 1.10-5.32) compared to men with a fasting RER less than 0.76. It was concluded that a relatively high fasting RER is a weak but significant predictor of substantial weight gain in non-obese white men.

Original languageEnglish
Pages (from-to)667-674
Number of pages8
JournalInternational Journal of Obesity
Volume16
Issue number9
Publication statusPublished - 1992

Keywords

  • Body weight
  • Metabolic rate
  • Respiratory exchange ratio

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