Fat distribution, androgens, and metabolism in nonobese women

J C Seidell, M Cigolini, P. Deurenberg, A. Oosterlee, G Doornbos

    Research output: Contribution to JournalArticleAcademicpeer-review


    Eighty-five randomly selected women, all born in 1948, were studied. All were nonobese (body mass index [BMI], 23.3 +/- 0.3 (means +/- SD]). The relationships between three indicators of fat distribution (waist-hip, waist-thigh, and subscapular-triceps ratios) and hormonal and metabolic variables were studied. Increased androgenic activity (ratio of free testosterone [T] to total testosterone [free-total T ratio]) and degree of obesity (BMI) were independently related to increased waist-hip ratio. Waist-hip and waist-thigh ratios showed higher correlations with all metabolic variables than did the triceps-subscapular skinfold thickness ratio except for diastolic blood pressure. After adjustment for BMI and free-total T ratio, the waist-hip ratio was still significantly positively related to total cholesterol and C peptide and negatively to the HDL-total cholesterol ratio. In such multiple regression, BMI was independently related to insulin, C peptide, and diastolic blood pressure. The free-total T ratio was independently related to triglycerides. BMI and waist-hip ratio gave important complementary information about risk factors for diseases such as cardiovascular disease and diabetes mellitus.

    Original languageEnglish
    Pages (from-to)269-73
    Number of pages5
    JournalAmerican Journal of Clinical Nutrition
    Issue number2
    Publication statusPublished - Aug 1989



    • Adipose Tissue
    • Adult
    • Androgens
    • Anthropometry
    • Blood Pressure
    • C-Peptide
    • Female
    • Humans
    • Insulin
    • Lipids
    • Obesity
    • Journal Article
    • Research Support, Non-U.S. Gov't

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