Femtosecond laser induced ionization and dissociation of gas-phase protonated leucine enkephalin

Geert Reitsma, Olmo Gonzalez-Magaña, Oscar Versolato, Meike Door, Ronnie Hoekstra, Eric Suraud, Bettina Fischer, Nicolas Camus, Manuel Kremer, Robert Moshammer, Thomas Schlathölter*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


We have combined a tandem mass spectrometer with a 780 nm fs-laser system to study photoionization and photofragmentation of trapped protonated leucine enkephalin cations for laser intensities between 2 × 1013 W/cm2 and 1 × 1014 W/cm2 and pulse durations of 15 fs. In this intensity range, the transition from multiphoton ionization and excitation to tunneling ionization is expected to occur. The observed partial ion yield curves as a function of laser intensity exhibit a power-law dependence, indicating multiphoton absorption to be the dominating mechanism. Pump-probe studies were performed to investigate the time-evolution of the multiphoton ionization process. The partial ion yields of almost all fragmentation channels show a broad but distinct maximum at a delay-time of approximately 750 fs. The particularly flat appearance of the pump-probe curves suggests that not a single resonance, but a broad distribution of resonances is involved.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalInternational Journal of Mass Spectrometry
Publication statusPublished - 15 May 2014
Externally publishedYes


  • Charge migration
  • Femtosecond laser induced dissociation
  • Multiphoton ionization
  • Peptide sequencing
  • Pump-probe spectroscopy
  • RF-traps


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