FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction

Maartje P.C.M. Luijk; Fleur P. Velders; Anne Tharner; Marinus H. van IJzendoorn; Marian J. Bakermans-Kranenburg; Vincent W.V. Jaddoe; Albert Hofman; Frank C. Verhulst; Henning Tiemeier

doi:10.1016/j.psyneuen.2010.04.012

FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction

Maartje P.C.M. Luijk, Fleur P. Velders, Anne Tharner, Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg^*, Vincent W.V. Jaddoe, Albert Hofman, Frank C. Verhulst, Henning Tiemeier

^*Corresponding author for this work

Clinical Child and Family Studies

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Quality of the parent-infant attachment relationship influences physiological stress regulation. Genetic factors also contribute to the stress regulatory HPA-axis. Quality of attachment as an index of the rearing environment (measured with the Strange Situation Procedure, SSP), and HPA-axis related SNPs (BclI, rs41423247; TthIIII, rs10052957; GR-9β, rs6198; N363S, rs6195; ER22/23EK, rs6189 and 6190; and FKBP5, rs1360780) were hypothesized to be related to cortisol reactivity in the stressful SSP. In this large population based sample, FKBP5 rs1360780, but not GR haplotype, was related to cortisol reactivity. Moreover, we found a significant interaction effect for insecure-resistant attachment and FKBP5 rs1360780, indicating a double-risk for heightened cortisol reactivity levels in infants with one or two T-alleles of the FKBP5 SNP and an insecure-resistant attachment relationship with their mother. Findings are discussed from the perspective of gene-environment interaction.

Original language	English
Pages (from-to)	1454-1461
Number of pages	8
Journal	Psychoneuroendocrinology
Volume	35
Issue number	10
DOIs	https://doi.org/10.1016/j.psyneuen.2010.04.012
Publication status	Published - 1 Nov 2010

Funding

Funding for this study was provided by grants from The Netherlands Organization for Scientific Research (NWO, grant no. 400-04-182, grant no. 452-04-306 (VIDI), and NWO SPINOZA prize). NWO had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, Rotterdam, the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR), Rotterdam. We gratefully acknowledge the contribution of general practitioners, hospitals, midwives and pharmacies in Rotterdam. The first phase of the Generation R Study is made possible by financial support from the Erasmus Medical Center , Rotterdam, the Erasmus University Rotterdam and The Netherlands Organization for Health Research and Development (ZonMw). The present study was supported by additional grants from the Netherlands Organization for Scientific Research (grant no. 400-04-182 , grant no. 452-04-306 (VIDI), and NWO SPINOZA prize).

Keywords

Attachment
Cortisol
FKBP5
GxE interaction
HPA-axis
Stress reactivity

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10.1016/j.psyneuen.2010.04.012

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title = "FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction",

abstract = "Quality of the parent-infant attachment relationship influences physiological stress regulation. Genetic factors also contribute to the stress regulatory HPA-axis. Quality of attachment as an index of the rearing environment (measured with the Strange Situation Procedure, SSP), and HPA-axis related SNPs (BclI, rs41423247; TthIIII, rs10052957; GR-9β, rs6198; N363S, rs6195; ER22/23EK, rs6189 and 6190; and FKBP5, rs1360780) were hypothesized to be related to cortisol reactivity in the stressful SSP. In this large population based sample, FKBP5 rs1360780, but not GR haplotype, was related to cortisol reactivity. Moreover, we found a significant interaction effect for insecure-resistant attachment and FKBP5 rs1360780, indicating a double-risk for heightened cortisol reactivity levels in infants with one or two T-alleles of the FKBP5 SNP and an insecure-resistant attachment relationship with their mother. Findings are discussed from the perspective of gene-environment interaction.",

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AU - Bakermans-Kranenburg, Marian J.

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AU - Tiemeier, Henning

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FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction

Abstract

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Keywords

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