FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression

Lyubov Bryushkova*, Clement Zai, Sheng Chen, Irene Pappa, Viara Mileva, Henning Tiemeier, Marian Bakermans-Kranenburg, James L. Kennedy, Joseph H. Beitchman

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalPsychiatry Research
Volume242
DOIs
Publication statusPublished - 30 Aug 2016
Externally publishedYes

Keywords

  • Child aggression
  • Gene-environment interaction
  • HPA axis

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