Fluorine-18 labelled building blocks for PET tracer synthesis

Dion Van Der Born, Anna Pees, Alex J. Poot, Romano V.A. Orru, Albert D. Windhorst, Danielle J. Vugts*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review


Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview of the available radiochemistry methodology is a prerequisite for selection of a synthetic approach for new fluorine-18 labelled PET tracers. These PET tracers can be synthesised either by late-stage radiofluorination, introducing fluorine-18 in the last step of the synthesis, or by a building block approach (also called modular build-up approach), introducing fluorine-18 in a fast and efficient manner in a building block, which is reacted further in one or multiple reaction steps to form the PET tracer. This review presents a comprehensive overview of the synthesis and application of fluorine-18 labelled building blocks since 2010.

Original languageEnglish
Pages (from-to)4709-4773
Number of pages65
JournalChemical Society Reviews
Issue number15
Publication statusPublished - 7 Aug 2017


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