Fluorine-18 labelled building blocks for PET tracer synthesis

Dion Van Der Born, Anna Pees, Alex J. Poot, Romano V.A. Orru, Albert D. Windhorst, Danielle J. Vugts

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview of the available radiochemistry methodology is a prerequisite for selection of a synthetic approach for new fluorine-18 labelled PET tracers. These PET tracers can be synthesised either by late-stage radiofluorination, introducing fluorine-18 in the last step of the synthesis, or by a building block approach (also called modular build-up approach), introducing fluorine-18 in a fast and efficient manner in a building block, which is reacted further in one or multiple reaction steps to form the PET tracer. This review presents a comprehensive overview of the synthesis and application of fluorine-18 labelled building blocks since 2010.

Original languageEnglish
Pages (from-to)4709-4773
Number of pages65
JournalChemical Society Reviews
Volume46
Issue number15
DOIs
Publication statusPublished - 7 Aug 2017

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Positron emission tomography
Fluorine
Radioisotopes
Imaging techniques

Cite this

Van Der Born, D., Pees, A., Poot, A. J., Orru, R. V. A., Windhorst, A. D., & Vugts, D. J. (2017). Fluorine-18 labelled building blocks for PET tracer synthesis. Chemical Society Reviews, 46(15), 4709-4773. https://doi.org/10.1039/c6cs00492j
Van Der Born, Dion ; Pees, Anna ; Poot, Alex J. ; Orru, Romano V.A. ; Windhorst, Albert D. ; Vugts, Danielle J. / Fluorine-18 labelled building blocks for PET tracer synthesis. In: Chemical Society Reviews. 2017 ; Vol. 46, No. 15. pp. 4709-4773.
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Van Der Born, D, Pees, A, Poot, AJ, Orru, RVA, Windhorst, AD & Vugts, DJ 2017, 'Fluorine-18 labelled building blocks for PET tracer synthesis' Chemical Society Reviews, vol. 46, no. 15, pp. 4709-4773. https://doi.org/10.1039/c6cs00492j

Fluorine-18 labelled building blocks for PET tracer synthesis. / Van Der Born, Dion; Pees, Anna; Poot, Alex J.; Orru, Romano V.A.; Windhorst, Albert D.; Vugts, Danielle J.

In: Chemical Society Reviews, Vol. 46, No. 15, 07.08.2017, p. 4709-4773.

Research output: Contribution to JournalReview articleAcademicpeer-review

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Van Der Born D, Pees A, Poot AJ, Orru RVA, Windhorst AD, Vugts DJ. Fluorine-18 labelled building blocks for PET tracer synthesis. Chemical Society Reviews. 2017 Aug 7;46(15):4709-4773. https://doi.org/10.1039/c6cs00492j