Folate overproduction in Lactobacillus plantarum WCFS1 causes methotrexate resistance.

H.B.A. Wegkamp, W.M. Vos, E.J. Smid

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Folate overproduction can serve as a mode of resistance against the folate antagonist methotrexate in Lactobacillus plantarum WCFS1. When compared with a wild-type control strain, an engineered high folate-producing strain was found to be insensitive to methotrexate. The growth rate and the viable count of the folate-overproducing L. plantarum strain were not significantly affected by the presence of methotrexate in the growth medium. © 2009 Federation of European Microbiological Societies.
Original languageEnglish
Pages (from-to)261-265
JournalFEMS Microbiology Letters
Volume297
DOIs
Publication statusPublished - 2009

Fingerprint

Dive into the research topics of 'Folate overproduction in Lactobacillus plantarum WCFS1 causes methotrexate resistance.'. Together they form a unique fingerprint.

Cite this