Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

Peter J. M. van Haastert; Ineke Keizer-Gunnink; Henderikus Pots; Claudia Ortiz-Mateos; Douwe Veltman; Wouter van Egmond; Arjan Kortholt

doi:10.1091/mbc.e21-04-0171

Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

Peter J. M. van Haastert
, Ineke Keizer-Gunnink
, Henderikus Pots
, Claudia Ortiz-Mateos
, Douwe Veltman
, Wouter van Egmond
, Arjan Kortholt

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Chemoattractants induce a fast cGMP response in Dictyostelium. The cGMP signaling pathway consists of a soluble guanylyl cyclase sGC, a cGMP-stimulated PDE, and the cGMP-target protein GbpC. Here we combine published and many unpublished experiments performed in the past 45 years on the regulation and function of the cGMP signaling pathway.

Original language	English
Article number	ar8
Journal	Molecular Biology of the Cell
Volume	32
Issue number	20
DOIs	https://doi.org/10.1091/mbc.e21-04-0171
Publication status	Published - 1 Oct 2021
Externally published	Yes

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10.1091/mbc.e21-04-0171

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van Haastert, P. J. M., Keizer-Gunnink, I., Pots, H., Ortiz-Mateos, C., Veltman, D., van Egmond, W., & Kortholt, A. (2021). Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis. Molecular Biology of the Cell, 32(20), Article ar8. https://doi.org/10.1091/mbc.e21-04-0171

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abstract = "Chemoattractants induce a fast cGMP response in Dictyostelium. The cGMP signaling pathway consists of a soluble guanylyl cyclase sGC, a cGMP-stimulated PDE, and the cGMP-target protein GbpC. Here we combine published and many unpublished experiments performed in the past 45 years on the regulation and function of the cGMP signaling pathway. ",

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Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis. / van Haastert, Peter J. M.; Keizer-Gunnink, Ineke; Pots, Henderikus et al.
In: Molecular Biology of the Cell, Vol. 32, No. 20, ar8, 01.10.2021.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Forty-five years of cGMP research in Dictyostelium: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

AU - van Haastert, Peter J. M.

AU - Keizer-Gunnink, Ineke

AU - Pots, Henderikus

AU - Ortiz-Mateos, Claudia

AU - Veltman, Douwe

AU - van Egmond, Wouter

AU - Kortholt, Arjan

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DO - 10.1091/mbc.e21-04-0171

M3 - Article

SN - 1059-1524

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JO - Molecular Biology of the Cell

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Forty-five years of cGMP research in <i>Dictyostelium</i>: understanding the regulation and function of the cGMP pathway for cell movement and chemotaxis

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